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In the past mnth some experimentel work has been carrlsd out on methods for mIlecCing CO2 and Futting i% into suitable forn for mdiosctiviI;$ masuronentc, Literature stcdbec are u d e r way concerning methods of organic synthesis and isoletion of various compounds from Two sanples of c rem tory ash were digested witB psrchloric and nitric QC ~ & S ~and the radon produced in kaown time Pntervals naeasurecd in an alpha countero %e measurements wew all near backgromd, Indicating that there w a s probably not over about 10”” grams of ash before digestian were accounted far quntita%tvelyo Only background act’rvitg vas obtained when one of the bone ash samples, which had been standing for ten y a r s , was analyzed for polomafum, The results obtained therapie 9. Tggl (19kZ) w h o reported an aver&@ of lPggrams of radium retained i n the bone ash of eighteen human crcmtory Case80 Smll amunts of radium added .e0 the bone
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3.4 Peramel of this section have continue8 t o cooperate with 14ro Bishop fn t h e stuQ of radiation effects. 3@5 a t e which lard be= exposed to single doses of X-irradiation ( f n porphyrin compound, ' qith th3 afd of Dro Kurt Stdoman, this phenomenon bs ,being b vest ie ted to determine whether 'this is a specific affect of Section Head -- Kurt slomon &a loonan concerning red incruststions observed aroma the mouth of rats irrzdiated with x-rayo nature a d probably oeetrr as result of dehydrntion, vestigats this phenoaimn are now under waya preliminary exparimenta have been carried out in cobkaboretioon w i t h These incmrstationa oesm to be of porgbyrb In our progress report for last month, results on oqe rabbit were presented kihfch indicated that following the ncli?hiet-rztion of o-jog powder (200 mesh) by fa&fletion a large fraction of the dose was gmdUnllY exgelled frm the respfratopy tract end appeared w i t h the sali.rp&
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I t h s ~been thought tha% the biological effect of redfation would probably be de torm bed, at least in part, by the rate a t which a certain dbse might be deliveredu made on anirpals which are suEJected to acute and chronic radiationwith the advoat o f the atomic bomb certain discrepamiss were noted in tho calculated and observed cifectao obssmed in animals subjected to ale th sl OF near lethal dose of radiationo the following oxperhaut was devised, This is partially bmught cat bg the observation8 ]In order to try to show that when x t was found that batween lOOr and ~ O O Twas close to the 30 daY LD, in rats in the orclinary scute experiment. Accordingly, one group of 100 rats have been given a dose o f 850r in a period of 200 minutes, and another gmup of 100 rats h:v@ received 8501- 5.n an interval o f 2 minuteso 'Jith only part of the ,data under analysis it 1s seen th8t tho mortalitg ratas are narkcdlp different. ' h e half value layer o f the radiation, distance eta, bavo been constsnt, the intensity b e b g controlled by adjusting the current t h r o w the x-ray tube, I t is planned to bvestiggt3 the effects of a similar dose of radiation to be delivered in the fractional second s&geo the construction o f an x-ray unit energized by discharge o f a high capaoity will goon be underwaye ' Some of the materials for this u n i t hsve arrived and assembly c tron Micro scope The hrge 0lectmn nfcroecope I s now inetalled and some preliminary electron micrographs have been rmds for the Dlvision of' gharmscology a8 8 part of their dust particle siae stUdieeu being set up t o accentuate the sbdous froa the vewal ~ a l Lparticles present in their preparations. A metal evaporathg unit is An emission type microscope 9s partially coqleted, T4Jo human eubjectpl preyionsly studied were readmitted to tbe rnetabolia ward for follow-up excretory sWd$as bdag carried out in colla'mratbn with
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The amfao acid nitroeen-creatinine ratio did not increase after administration of uranyl-nitr=ite just as reported for tiant 19 Neither the urbary catalase activitr nor the ~ n o u ta i Udmr3 protein was significantly fncrzsed after the akin irt rat lon of uranhZb