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Lawrence Berkeley Laboratory HEALTH, EDUCATION. AND WELFARE PUBLIC HEALTH SERVICE COUNCIL (Month, Year) DATE RECEIVED TO OE COMPLETE0 BY PRINCIPAL INVESTIGATOR Itterns I rhm& t e n d 15A) ECT COSTS REQUESTED FOR FIRST 12-MONTH PERIOD On colo gist) Lawrence Berkeley Laboratory University of California Lawrence Berkeley Laboratory University of California 12. NAME, TITLE, ADDRESS. AND TELEPHONE NUblBiR OF OFFICIAL I N BUSINESS OFFICE WiO SHOULD ALSO BE TO 8E COMPLETED BY RESPONS18LE ADMINISTRATIVE AUTHORITY fIr.?ms Crhrough U a n d 159) Regents, University of California ' Associate Director for Admin is tr atb Lawrence Berkeley Laboratory University of California Berkeley,. CA 94720 -7.740&51:Telephone Number 41 5 ff 4 7 FOR INSTITUTIONAL GRANT PURPOSES I* lrurrucrionr) 10. NAME, TITLE, A W TELEPHONE NUMBER OF OF FICIALIS) SIGNING FOR APPLICANT ORGANIZATION(S) Associate Director for gents of university of mi for nia Administration Lawrence Berkelev Laboratom - 16. CERTIFICATION AND ACCEPTANCE. Vdo, the undenignyd,, csnlt{ that thn dr.emmu herein U. m f o and Fomplste 10 th9 bert Of 01lr knowladip end accept. BS to t n y gent awarded. the otlimtion to cornply with Fublic Health Sawlm tsna m d eonditions In d f M et (hc timeof thJ
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PRIVACY ACT MATERIAL REMOVED DEPARTMENT OF HE#?LTII. EDUCATION. AND WELFAHE PUIJLIG HEALTH SERVICE NAh% AND A ODR ES OF Af'PLICAfJr ORGANIZASION I LAWRENCE BERKeLEY LABORATORY, UNI VERS ITY OF CALI FORN IA, BERKELEY CALI FORN I A 94720 NAME, SOCIAL SECURITY NUMBER. OFFICIAL TIT1.t. AND OE?AnVM<NT OF ALL PROFESS.IONAL VEFISOIJNEL CCSAGEU bEJ PIIOJECT, DEGlNNlNG WITH PRINCIPAL INVESTIGATOR 8 , PRINCIPAL INVESTIGATOR, Prof, Radiology, UCSF/LBL; CO-INVESTIGATOR, Pro;, Div Med Phys, Donner Lab, Dir, Donner Lab, LBL; Biophysicist, Donner Lab, LBL; Asst Clin Prof, UCSF; Consulting Pathologist, LBL; ,Ch, Div Radiat Oncology, UCSF; TREATMENT OF CANCER WITH HELIUM AND HEAVY IONS USE THIS SPACE TO ABSTRACT YOUR fROPOSED RESEARCH. OUTLINE OBJECTIVES AND METHODS. UNOEHSCORE THE KEY WOROS This research project will study the therapeutic application of BEVALAC-producad heavy ions such as neon in the treatment of human cancers. biological parameters for heavy ions are being evaluated, experience will be gained in fractionated, large-field, extended-Bragg-peak radiotherapy using helium ions available from the 184-in Synchrocyclotron. beam are well established. implementation with the helium-ion beam will be invaluable in carrying on irradiation with the heavy-ion beam. studies will be performed. study primarily effects of improved dose localization) and heavy ions (to evaluate both the effects of improved dose localization and the potential radiobiologic advantage of greatly lowered OER (oxygen enhancement ratio)). The radiobiological parameters of this The experience gained in treatment planning, setup and Pilot studies leading as soon as possible to controlled Controlled studies are planned with both helium ions (to
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Max L.M. Boone, MD, Dir, Radiat Oncol, Univ. of Arizona Med Ctr, Tucson; BAY AREA HEAVY-ION ASSOCIATION (partial membership listing) Malcolm Bagshaw, MD, 1 Prof b Chm, Radiology, Stanford Univ Med C t r ; Barry Chauser, MD, , Radiat Ther, Peninsula Hospital, Burlingame; H. Anthony Engelbrecht, ED,. Radiat Ther, Peralta Hospital, Oakland; David Karp, MD, , Radiat Ther, US Naval Hospital, Oakland; Bernard Lewinsky,.MD, Chief, Radiat Ther, Letterman General Hosp, SF; Lawrence Margolis, MD, Radiat Ther, Ralph IC Davies Med C t r , SF; Theodore R. Purcell, MD, 1, Dir, Radiat Ther, Alta Bates Hosp, Berkel'ey; Antolin Raventos, MD, Prof 61 Chm, Radiology, UC Davis; Alan Schroeder, MD# , Radiat Ther, Santa Rosa Med Ctr, Santa Rosa; Saul silverman, MD, I Radiat Ther Ctr,Sutter Hosp, Sacramento; Attending Radiat Ther, Memorial Hosp, Sloan-Kettering Radiation Oncologist, Zellerbach Saroni Tumor , Head ,Physicist, Zallerbach Saroni Tumor Inst.