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Machine-read from the scan, so expect some errors. Lines that couldn’t be read are left out.
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Inter agency Agreement No. of High Spzed Flow Systern >letnods of Cell Andys is arid Sorting to CanccrRelated Cell Po-plations" is being entered into between theU.S. Energy Research adD melo pn ent Agency and the Xatiorial Institutes of Health, N atl on al Cznccr Institute, as used here in,the tesa EiCDA/TYXSL shall mean oBerated by the University of California under CoEiract 1;-7405-GIG-36 with WlIEICAS the parties do nut u ally agree to mefid the Agreement as follows: Section I - Introduction - Beginning vLth the effective date of this A. The EI?DA/LASL shall exert its best efforts to eva luz te newly dcvelo2ed and presently es is ting staining and pre para Liz na1protocols, atten??t t o develop new diz gnostic markers, and assess the value of light scattering 6r.d Fourier optics tech $ ues on clinical c zte rial as nethods suitable for cancer diagnosis. The ERDA/LASL shall ic ? len ent onlv " a e in strum n tai inprovements wlli r-1 Dr on cte thn,sE obi ect iv eg. This program is described more fully tn the ERDA/L.4?Td Tech ical Sorting and Analysis. 'I referenced above is incorporated into and x idea part of this agreement as though fully set forth here in ; except, however, inthe event of a coil fl ict between said Technical Proposal, and. an;. ocher tcrrrs 3nd conditions of this agr zen ent, then ail other i em snd eon d it i ox of this a gre ment shall Czke preceder,ce aver the EWA / 1. Obtain a n adequate supply of bcth normal and abn or nal cervical and vaginal saniples. to be delivered to the the period GZ c his modi fic z tion.Atleast fifty per cent of the abn or a al ~ 212 ~ 1 ~ ss hos ld be classified as
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I. ragency Agreement So. 2. Conduct ? rel imina ry experiments with clinical material using various staining and preparation al proto c Is t o evaluate their usefulness in cancer ii a gnosis. techniques which yield success i ui results shou l used on a larger number of noma1 and abnormal samples, and results(including both false positive and false Sorter 111 located at the NCI. 4.Construct and deliver to the NCI the following items for the above cell sorter, on the specified delivery a ) Two time-to-axxplitude converters to be delivered to t h e KCI by Nay 31, 1975. A simplified flat flow chamber to be delivered to the c) An electronic circuit which can distinguish a single cell from a dmb let to be delivered to the NCI by Two additional flow chambers of the type already on Sorter 111. Ofie should have aC3u lter orifice of 75 microns a d the other 217 orifice of 90 microns. Both should be capable of fo d ngd roT lets at distances suitable for sorting. 5 . On or before llarch 31, 1976, ETU)X/LSL must de non s crate to the satisfaction of the Project Officer,data or: clinical nzcerial using the newly developed mlti - angle lights cat t cr iim sjs~eeriiw iiici : indic as esc ii h ichi sier - h : i ~ que has po cc irt id in the dia gii csis of mal.i,onancy. 1. The ERDA/LASL shall submit to the Project Officer, by September 30, I475 four copies of a progress report for the period u ary, 1975 through August 31, 1975. A report be submitted with the next renewal gr-oposal. Each report shall include a brief description of work peri or ned durin q the period reported upon, problerrs i f zny, and the act ici pate d b:ork plan for the following period. in fourc opie s+Tor :he period fro3 September 1, 1975 shall
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Inter, ncy Agreemenc No. 2. The ERDA/LASL shall also submit a bri.ef suminary of salient results to date and a summary of the final report upon couple tion or termination of the agreement. 3. The progress reports shall be no longer than five(5) pages of text with unlimited tables and graphs each of which will have less than one pzge of explanatory test. The reports should include decision points and other specifics, such a s number of clinical specimens used,pathological classification of specimens, nuder of cells tested if appropriate, etc. It is the task of the Principal Investigator to integrate rep crts from other subcontractors so as t o comply with the require cent. Reports consisting of more than five pages of text will be conside red only for the content of thc first five pages. 4. In all publications resulting from research per for ned under this Inter agency AgreeneEt the ERDA/LASL shall c ck x w led Ze sup Fort of the National Cancer Institute under Inter sgen cy Agreement :To. 5 . "Manpower.Report. In addition to any other reporting require - 2 ment of this Agreement, the ERDAILASL shall ' complete an annual the instructions contained there in, The parties agree th z t this reports hall not be used for reconciliation swit li ' other fiscal reports or for any other fiscal or accounting purpose." /7 It i s hereby understood and agreed that studies involving human subjects shall not be conducted under this Agreement, and that no material developed, modified, or delivered by or to the Cavernnent under this Agreeiaent, o r any Contractor or made available by hirn for use by anyone other than the Government, for eq eri mental or tn erap iu tic use on humans without the prior written approval of the Contracting 1. For the period April 1, 1975 through March 31, 1976, the ERDX/LASL agrees to utilize personnel in the following cet ego ries for.the approximate time indicated : Cat e gory Approximate No. , of & mud Pian-Years--
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2. The ERDAITASL agrees to use his best efforts to a ccc np li shall the work' outlined or referenced above. deemed complete ifthe work is performed i n accordance with high standards oE scientific and professional skill and the approx iz atc lsvel of effort has been diligently a ppl led,except, however, all other require cents Gust be met including delivery of reports and mterials as may be required under the contract. His obligations will be Section I1 - Tern - Se ginning with the effective dace of this Eod if i cation, i s amended by deleting Xarch 31, 1975 and su3st it u ting March 31, 197G the ref cr. of this Nod if ica tic n, is amna-cd by deleting $937,700.00 and substituting $1,285,90C.00 tn ere for. This represents an increase of $348,200.00. Prior Authorization of Certain Dcrect Costs Prior authorization in writing by the Contracting Officer is required for the costs listed below. Their incur rence with the intent of claiming reimbursement as direct costs shall Rearrangement, alteration,or relocation of facilities. Any fee or other payment for consult a tic n. Overtime, shift,or other incentive premium. Travel € or general scientific meetings and all travel outside the United States. Any rental agree m nt for real or personal property. Pf odi fi cation,is hereby anended ta read as follows :
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Sect i cn IX - Key Personnes - Beginning with the effective date of this Modification, is hereby amended as follows: The key personnel cited below are considered to be essential to the work being performed hereunder. In the event the assigned individuals leave the EAWA/LASL employ o r are reassigned to other programs, the ERDA/LASL shall notify the Contracting Officer reasonably in advance and shall submit permit evaluation of the impact on the program. No diversion or replace l lent shall be made by the ERDA/LASL without written consent of the Contracting Narylou In gran, M. 3. Section X - Advance Understandings - Beginning with the effective date of this Modification,is hereby added as follows : shall not incur costs of more than $5,500 for vaginal and cervical samples, witS out prior authorization of the Contracting Officer. this Modification, is hereby added as follows : Beginning with the effective date of The ERDA/LLSL is hereby authorized to acquire the property listed in the attached Schedule I - A for use indirect performance of the Except as here in provided, all other terms and conditions of the Agreement shall rcriain in full force and effect. Develop ent Agency Department of Health, Education & National Institutes cf Health National Cancer Institute
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ERDA/LhSL Acquired Permanent Equipment Biomation 610B Waveform Recorder Unit Gravity Sed. Apparatus Thin Layer Chromatography Cy t ocen trif uge Cell Washing Centrifuge Canera Attachment t o U. V. Scope Interface for IBM Tape Unit to