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SCI. ZE INFORTMATION EXCHANGE, 4-C. I AT CHIC ENERGY COMMISSION BIOLOGICAL EFFECTS OF IONIZING BADIA TION AT THE NOLECULAB, CZLLULAR AND HUMAN LEVEL IPRINCIPAL INVESTIGATOR, ASSOCIATES AND DEPARTMENT/SPECIALTI: RECIPIENT INSTITUTION: PERIOD FOR THIS NRP: SCHOOL OF YE DI CINE FY71 FUNDS 342,000I ROCHE SEA, NEW YORK 1462C I SUMMARY OF PROJECT: A cell cycle analysis of the incidence and repair of radiation - in du cid single and double strand DNA breaks will be done with L517dYand Hela cells,The repair of single and particularly of double strand breaks will be compared with the ability of. the cell,atthe same age, (1970))has already shown that in synchronous Hela cells,repair of sub lethal damage occurs to a much g rza ter extent,if not exclusively, during G1 ard late S than during other stages of the replication cycle. Since the progression c cmp one nt of El kind - Sutton type recovery had been taken into account,any molecular repair responsible for the repair of sub lethal damage should also occur to a much greater extent a t these The plan arian will ba used as a model system for the study of stem cell population kinetics,particularly with regard to the loss of different i at ive integrity and the animal ' s mechanism (s) for the control already shown the useful n2ss of the plan arian for such studies and work will continue alang the same lines. B study of former plutonium uorkers with plutonium body burdens will be continued and thorough medical examination,including urine analysis and lung cou Ets,ofas many of these men as possible will be Results : As ystEin for automated gradient analysis has been developed and construct ad,such that experimental points may betaken every two hours about the24hour Hela cell cycle.Experiments with L5178Y acd Hela cells are now in progress.A plan arian laboratory has bo en outfitted and a relatively local source of Dug ssi alu gu bris has
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SCI. CE INFORMATION EXCHANGE, NOTICE OF RESEARCH PROJECT 1 I PLANNING FOR CANCEB RESEARCH TRAINING & PATIENT SERVICE I PRINCIPAL INVESTIGATOR, ASSOCIATES AND DEPARTMENTISPECIALTY: D R TC HALL EX PER INEN TAL RAC I OLOGY UNIV. OF ROC3ESTER6 / 7 1 TO 5 / 7 2 SCHOOL OF BE DT CINE FY71 FUNDS $58,235 SUMMARY OF PROJECC For a comprehensive study of the pot anti al of the University of lio chester Hedical Center and its affiliated hospitals in the field so cancer research8training and patient service.This is a critical juncture in tile development of this s cho cl since an inter deF art ment a1 Division of Oncology has been created, affiliations arit bG ing comp let with all the major hospitals in Monroe County and leadership of the it e gional Medical Program has been vested in this school. IE addition n cu Has pita1 is being constructed, and relationship with community healthcare and voluntary cancer organizations are being intensified.