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CANCER RESEARCH INSTITUTE NEW ENGLAND DEACONESS HOSPITAL Liochemis t,X ed ical Research Branch 3i vision of Biology & Ned i cine fora ,irrr AEC contract to replace the existing one. First,let me comtxnt on tile study of the plutonium workers. 9r. Hempelmann is not only 4iZiily skilled.in epidemiologic work but has a very winnin.5 personality 7.diic-i is extraordinarily helpful inn aiz tai nine,the interest and cooperation of tiie personricl being studied. aid talents ? rit ti those of J3r. Lange siiould produce a very helpful treatise on the loiig-ranZe effects of body burdens of plutonium. I n 1i:ht of the receiit unhappy publicity related to Rocky Flats,it is particularly ir;.,portant for the AEC t o have as much information as possible on plutonium body 'ourdents. Iam very happy that a fifth of tne series of examinations are to be carried out on tn ese persons. You and i)r. Golds tien are tobe congra tula ted on suggesting and facilitating this work. be feasible for Gi3i1 to support this phase of the contract. The combination of h i s knowledge I hope that it will With rez ard to the cyto logic work I regard this as important. de know too little about the repair of radiation - induced breaks, and 1)r. Lange's vor k with lieLa cells siiould be of consider aLle value here. One ninor concern thatI have is that iieLa cells are clearly pathologic,:: and It rust that s one parallel work will be done with normal cells.I could not be sure from the protocol whether the mamaliar, cells mentioned i n paragraph 1.d on page 4were norn al cells or not.Ian not familiar with plan aria but from what little I do know, I would feel that Dr. Lanze's work i s well worth while. The interplay between plan arian.differentiated and sten cells is an important Sio1o;ic phenomenon and appears to provide a ratner clear - cut way of studying feedback mechanisns as related to pro l if - e rating stem cells. Is this situation perhaps a very crude analogy to that between the maiimalian erythrocyte and e ry throb last ? synthesis in rp ogress ion through tlis cell cycle in presses ne as likely to provide important information as to in vivo protein synthesis. AS t o enzyme activity durin z the cell cycle,I note tii at Xr. Capp will be working i n Tokyo for the first half of tiie year.In view of tiie excellent work being currently done i n Japan, this should be very profitable and augur wcll for tile future success of this phase of tiie work. The role of protein
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I would recommend strongly that the projects outlined under this contract proposal be supported. show diverse enzymatic and other biochemical variations and there are apparent differences in chromosomal makeup, although there is not a spec i - fic relationship between alterations in chromosomal structure and alterat ions in functional behavior. I have i n mind the fact that the study of clones of HeLa cells