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Clinied remireion of mycodamr c a n be effected by contfnuoufi admidstration of thyroid, thyraxkaa or trfiodothyrosrins, and rrbilo this roepaare to therapy producee m e of the most gratifying r a + dtr kr clinical Ttm diocorery of new biotaqkally active analogues of thyroxins h s ~incrcrsoad rP.auuretn6nt of the rate o i incorporation or loa& of radioiodl9.r by tba ttzprdd aacb dry (1# 2, 31, ab compared tc, 3.084 mg. af t&yrc#kreper dap wkicb dirrpprrrre from the blood (res ChpLsr 00). Thb discreprtocy ruggeatr that
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Myxrdarru c m be controUed by thr crdrnfniatrcraion of 0 . 0 5 to 0.1 mg. nloso of t!ie order of 1 pg. Ok are too amall for rc c urata dettlerniimtim by current clinical. laboratory mctbods.
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theoretically-, atha ot 42% of the fhytcntina from the bled would be excreted ia the fixer.
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ord thyroxine vbuld have been excreted Ln the fecrr d u n three d8yr. b order t o investigate tkh natter furth under phydalqicrfi coDduLopl tha excr'dtion of rrdioactsva fodhe w a 8 8tudisd fohwbgt at81 a d urW8vrplaar administration of tracer dorers ~f 1131 L-thyroxine t o normal yecple anti to paopla taking 180 m g . of thyroid per day. The urine enu !e.ccs werec ~ ' ic.rx3C ezch day for 4 to 10 days. Five to ten microcurler of f roprsaantod unabrorbed thyroxine or entsrohmpsttc thydm pl(?Oductl. fhue an average of 3% of tho tricor dcue wa@ It ir M rlwr wbetbr thio fecal
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than 5% of the radioactivity). Bucb contrminrtior, would b e largely exctcrtrd 40% of orally adrnirrittersd E-thymxiae ! a no: ~ h p u r b e dor is rapidly cycl-ad aay6 fdlowing iajection 1 % to ZO?k of t h e daily excretion of radioactivity w o s found in ths fete#, on the third day half t k a caxcrcstiaa w a s fecd., and cm thu
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pamm QL rrcrstiou d iodine c ~ ~ ~ ~ p ~ u n d afrcam thyrcdnr, then 29% of the h d h a of tb extrathyroidal thyroxine lort daily would h utcretlbd ia th* faces YBd 71% in the urine. Prarunpabfy the fecal idns would be primarily band in organic combinatfan while the urinary fadine w o u l d be primarily inorganic normal men. Xf thyraxino war; released from the thyroid by i & e a t U a d war dxod with the radioactive thyraxtm, thaa thsae data wwld sugge ~ t tbt the thyroxine from thyroid givrsn orally i o absorbed okhifmrly t o L-thyroghne, beixsgr. Bath uriae and facd iodfm nerr drt ~ rmb dby tha chloric add bys. Tabla 2 rhoffll a krSu VU ir bUy in tb6 fecal urctetion of iodine by a o d W n beings, If it era bu assumed that 99% of tha dietary iadiaa ir
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uptake of radioiodine, muat axcrete a major fractiaa of hia thyroid h ~ r m ~ ~ l i PLa rmsult fn an iacreeee in tbc percmtttge of tal dietary iodhn. t o be bmt pfai
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sxcretsd in the faces ma.; 'us lsrgaly derived from endcganouo thyroid hormcnrc; the loss by thin route i n variabla and when dietary iodine i e low it may ba laa. mkht r l r o (~ccottrlLtfor varktion in oral doaa required for effective thenap7 of nptederm or suppreseiom oi the thyroid uptake of radidodiae.
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