Details of Isotope Procurement

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Most do tui ls concerning the availability, aechanism o f allocation, nnd procurement of radioisotopes produced by the Manhattan Dist riot are given in the official Manhattan Project announcenent, " kv a ile bil it y of Radioactive Isotopes ? " Science, Vol. 103, pages 697705. June 16. 1946. (A revised sot of tmf available isotopes uppears inthe Septelnber 1946, Reviev of Scientific Instrvraents .) It was not possible, however, t o give i n =e announceilkent details per ti - nen t to the prbpartttion of the forms used for requesting, approving, ordering and shipping. ing the procurement' mechanism. This semorandun is for the purpose of explain6,Isotopes Branch, hknhattcin District The Isotopes Branch, Research Division, Manhattan District, does not allocate isotopes for use by investigators nc t working on the properly complct'ed and filed with this cffic.e, has been approved by sub-comQittees of an Advisory Co,mittce on Isotopo Distribution Policy, Members of the cox x it tee and sub - comit t ces have been appointed with the guidance cfthe National 1,cadeny of Sciences. other organizationG1 mt terser e given in the crt iole in Science) Allocation of rnatorial i s rnadc only after a request, Their nanes and The Clinton LabGratories, Xonsnnto Chemical Conpany, Oak Ridge, acting under a contract with the United StGtes Governnentr i s active materials when such - sales are approved by the Manhattan District, Corar.iuniccticna tothe Monsanto Chomiccl Company should be addressed t o the Isotopes Offir,e, Clinton Laboratories (do not confuse with the CI Institutional Isotope Conn it tees Isotopes will be ixade available to individuals only through qualified institutions.Itis rscomnecded by the advisory groups that each institution es tabl leh a local UradicFsotope com i it tee " to(a) approve all requests for radioactive isotopes, (b) coordinate the use of such materials within the institution, and (c)effect possible economies i n procurement, particularly fc r short hcl f - life materials, by rileans o f combined purchase8 for several do part n ents of the institution, Tho local cox n it tee should contain (1) a physicist or other person qualified to advise cn the proper selection and measurement of is ntu pes,(2)a parson f ' mi liar with the biological effects of radiation and qualified to advise on health - s cfc ty procedures inthe handling o f

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radioactive nate rials,(3)ache nist cr radiochemist to advise on the contaminhnts, synthesis of labeled compounds, e t ? .) and of extra ation for measurement, and (4) such repress n tet ives of the using groups as m y be desirable. One parson may qualify In some cases for more than one ofthe above require a ents, mitte e will see that all radioactive m te rials are used under safe conditions and that personnel and laboratories &Ye mcnitored for radi - ation and contaminction. should be designatod by the ad n in is trs tion to forwtrd a11 requests from the institution to the Isotopes Branch, . I n some institutions the local comThe chairinan of the a omit tee and and ternate In the case of medical SchoGls, clinics, and hospitals where use i n human beings i s involsed, it i s recommended by the sub-Committee on H mri App lica ti cns th ct the loc til .isotope committee be compcsed of atleast three neinbers a s follows; f1) a physician well versed inthe phyaholbgg and patholmgy af blood-forming organs, ( 2 ) a physician w e l l physicist,radiologist,or radiation physiologist qualified in the teohniques of radioisotopes. The administration of the institution should advise the Isotopes Erm ch of the composition of the local corn it toe or comrnitteesb the special fields of the members, and the desired arrangements for the forwarding of requests. Form Used i n Requesting, fLpproving and Ordering Radioisotopes lr Pre lis in ary inquiries r rite to the Is otc pes Brunch, Pesearch Divisi cn, Manhattan infor mu tion .District, Ouk Ridge, Tennessee, concerning availability of 2, Interim Period Request for Radioelement, Form 313 Three copies are to be for-mrded to the Isotopes Brarich the front mid beck ofthe pcge, ofthe photographic process used i n reproducing the add it ion el copies noedcd for processing an application. c5py isto be typed with carbon paper fao ing This is necessary bemuse c. Requests arts filed by serial numbers assigned inthe receipt of yclur request. this nu ~ ber * ,, Coqrcspondence sholdd refer to

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dah Check each ite:n cf the request for completeness before mailing the form.. Pri crit y rating is applied solely on thi: busis of Ln form tic n given on the request fcrmz orcission of R detail may delay approval or lower.the sive,are especially important in this regard.. Request radioelements on formal request forms only in the form and units ES des crib cd in Science or in lists furnished by th a Isotopes Brcmch. The desired specific activity and desired form of material should actually be entered inthe spaces provided for these items, but the entries for the minimum value of specific activity and the accept abl of or m should permit fulfillment with described itens, Inquiries concerning other desirable specifications and amounts are invited but they should be addressed tothe Isotopes Branch number cf users mike known their desires in regard t o changes inthe forms, specific nc t iv it y,.purity, etc.J of supplied mete rials,steps my be taken t o improve o r expand services. 3.. Supplementcry Request f o r Radioelement,, Form 335 a*. Use only for ordering more o f D. previously allocated materi al for the sane research purpose. ti ties of isotopes are naeded for a different research b, Forward the same number of copies prepared inthe same manner as Form 313. e a Use the s a ze care in oompleting each item as for the orig i - c rigi ncl request in use of mter i alor in spec iff cations. Ncta particularly any rnodifiaations from 1, Radioelement All c cation km r oval. Form 374 a. The serial number will be identical with then mbc r assigned t o your request, Forn 313 o r 335. Origiriul a s prepared by the Isotopes Branah is forwarded t o the in sti tui on and a copy is sent the supplier. C. Original is for your files and isto be retained by yout d. Notify the Isotopes branch inmediately cf any error. e . Form 374 includes instruct i cns for procurement ofthe radioqui red in certain cases by the Federel Food, Drug, and Cosmetic Aot)are discussed below. Details concerning "kgreexent" Form, mailing o f

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fd The Isotopes Eranah only cpprovos in general the shipping livery will be arranged through the Isotopes Cff is e,Clinton nr M nil to : The Isotopes Office, Clinton Laboratories, bi' Do not mil n purohtse crder until you receive "Radioelement M location lrpproval, )' Form 3 744 C . Order only the radioelement and amount approved on Form 374, d. Refer to the serial number o f Form 374. e a Three copies of the "Agreement and Conditions for Order and Reeeipt o f Radioective Material" must accompany the first purchese order from an institut ui on. will be necessary only if new applicants are involved, 2. Agreement end Conditions f o r Order and Receipt o f Radioactive e + Three eo pies must be filed with the Isotopes Of fie ej Clinton Laboratories, before shipment can be made. Persons whose nanies appear a s " applicants, " item6 of request forms, and th6se who supervise the use of radioisotopes must be li r ted on the Agreement Forms approved by the institution for receipt of nate rial. b, It is re com ended ' that insofar as feasible a single "Agreesent " be negotiated that will include all applicants and all departments authorized to request and purchase radioactive materials for the institution. 3 , Agreement and Conditions for Transfer of Radioactive Materials a , idust be negotiated by a "secondary" user, which is defined as (1) an institution cooperating with the purchasing inst it uti on in a research problem, (2) an institution which desires to obtain surplus or residual material from the purchasing institut i cn,cr (3) o conuneroial consulting labor at cry employed by the purchasing institution to process materials or measure activities of materials which will be used under the latter ' s supervision4

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b i Written permission of tho Isotopes Branch is required before such a transfer can be made. c i Three copies nust be filed with the Isotopes Office, Clinton La bur atc rios, if parmission for the transfer is granted,Additional copies are also prcmided so that cne copy each may be retched by the original end tho 4; Cert if i cat e-- Required by tho Federal Food, and Drug Administration a, Three copies must be filed with the Isotopes Office, Clinton Laboratories, when radioactive materials will be used a s of disease,or any investigation al use involving huxan beings or anim K b. The " Certificate " must be signed by the person conducting tho inve sti gat ion., c i The investigator should be prepared to furnish information on his findings to the Federal Foc.d and Drug Administration. d. k " Corti fic dte " must be filed for each new research project (new isotopes or new use); that is., each new application Forin 313, even though by t h e same investigator.. The supplier is not ' resp cns i ble for delivery of m te rialto the requester,but will properly pockcge material and arrange for transportation,insofar as possible, as designtited by the reShipments are made F.O.B., Clinton Laboratories,Collect carrier chargus will be paid by there ce i ~ i n gi n st it uti on. Shipnent should be consigned t o someone prepared t o pay the Details regard i cg delivery and special timing of shipments should be arranged with the Isotopes Office, Clinton Laboratorias. Gam ray emitters will be shipped in a returnable container ; X deposit will be required on returnable containers ;

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e+. Dexnrrape will be charged on containers rete in ed over Instructions for opening spec i ol containers will be included 6. Airlines listed below do not accept shipments of radioactive materials. Do not plan air express delivery if tho shipment nust be carried hy Gne of these lines. All American Aviation,. Inc. Inland h i r Lines, Inc. Nat ioc al Airlines,. Inc. Northwest A i r 1 ines,. Inc.. Tiestern hir Lines, Inc., i'rices published in the official price list represent production costs only based on "out-of-pocket" expenses tothe Government., These p ricas are subject to change,. depending on production and sale8 experfence,. and will be revie-ired per icd ics l lye.kflat charge o f $25 i s added t o each shipmerAt t o cover handling and administrative costs including phak&ging,, monitoring, cccounting, etc (Note exception below.) Val Repeated Series of ShipmentsRequests for redi cisc to pes with a hdf - life of no greater than thirty days may be approved,. i S necessnry for the proposed research,. with the prcmisi.cn that delivery will be made in a series of shipments tine productior, level my be anti o ipa ted, it i s intended thaB shipments i n such cases will ncr ml ly be request ad from the allotment cn the basis of fairly regular mounts per unit tiae (week, two weeks,, month), Flexibil it yin aciounts per shipment will be permitted sub je otto the limitam t ions set by th supplier on the basis of production schaduling. Be. Hendling Fse In case a single purchase order is completed t o cover the series of shipments in the al locution,.the hcndling and administrative charge will be ruduoed t o $10 on all but the initial shipmentc handling and administrative oharge rem in s at $25 on a single shipment or the c rigi ncl shipment on each re qu sst filed and approved.

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Cq Flexibility in Repeated Shipments The purchase order my state the total allocation and the normal quantity desired shipped each week, every two weeks o r monthly" Arrangements may be made permitting a ohenge, either increase or dearease, in the stated rate of delivery by notifying Clinton Laboratories of the desired change I n advance by the number o f days required for proper produotion scheduling, Before an allotment has been used up conpletely, a Form 313 o r 335 should be submitted aovering needs for another period of six monthb, o r less, as desired.

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II FORM 313 I INTER IM PER I OD REQUEST FOR RAD IOELEMENT 5 . NAME OF INDIVIDUAL MAKING APPLICATION . ?@ d l pages Of this set (313, 31b, & 3Mb) with mrbm urmnged as showi below. Send Mig i ml ad ttu ~copies. FIRST CHOICE DTMER ACCEPTABLE FORMS 3. IF MATERIAL IS-TO BE USED SECONDARILY IN OTMER DEPARTMENTS OR I N COOPERATION WITH OTHER INSTITUTIONS,GIVE DETAILS 16. IF TOTAL AMOUNT I S NOT NEEDED INITIALLY OR CANNOT BE INITIALLY SUPPLIED ~ SPECIFY LEAST AMOUNT TMAT CAN BE USED AND SUBSEQUENT DELIVERY RATE. m. ESPECIALLY UNDESIRABLE CHEMICAL CONTAMINANTS 21. OTHER DESIRED SPECIFICATIONS

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22.ORGANISMS TO BE STUDIED (hml 23. APPROXIMATE NUMBER EXPERIMENTAL DETAILS (ALL USES) 26. BRIEF STATEMENT OF INTENDED USES fa w e UB Mp tc army be attached) 2%ACTIVITY TO BE USED PER ORGANISM 27. SAMPLES WILL .BE MEASURED IN FOLLOWING FORM (ash, gas, l i ~ i d ,e k . 1 28. GEOMETRY OF SAMPLE TO BE MEASURED fthtn flat, sM7ol(nds colmter, etc.) 30- EXPECTED ELAPSED TIME BETWEEN RECEIPT OF MATERIAL AND LAST ACTIVITY AS SAYS 319 NAME OF PERSON WHO WILL SUPERVISE MEASUREMENTS 32. EXPERIENCE OF 31 ABOVE r HEALTH PROTECTION AND SAFETY 33.DESCRIBE INSTRUMENTATION AVAILABLE AND EXPERIENCE OF PERSONNEL IN RADIATION MONITORING FOR HEALTH PROTECTION DISPOSAL AND SALVAGE 3’+* DESCRIBE PROPOSED METHOD OF DISPOSAL OF LONG HALF - LIFE OR LARGE ACT tV IT Y SURPLUS MATERIALS 35. IF DILUTED SURPLUS MATERIALS MAY BE USEFUL FOR OTHER RESEARCHES STATE DETAILS AND AVAILABILITY

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36- PU6LICA i lONS ~ O NT HIS OR RELATED PROBLEMS BY THE INTENDED USERS ARE FOUND I N (1- fa @'@=* In the event aHlicant has no.#ublishd articles use qbce for nanes of perscns faailiur with researches.) JOURNAL PAGES DATE '37. RESULTS OF INVESTIGATIONS USING REQUESTED MATERIAL WILL PROBABLY BE SUBMITTED FOR PUBLICATION TO: ~ T R :Shikrents are t o be made a t the rewst and acbense o f the regll%stm 38. I T IS REQUESTED THAT MAl TRIAL BE PACKAGED FOR SHIPMENT VIA THE FOLLOWING AUTHORIZED CARRIER 39. GIVE SHIPPING ADDRESS REMARKS OR ADDITIONAL DETAILS (Refer to item by Number) urnanittees nominated by the Natkmal Acadeary of Sciences a d that he has no objection to the d i s c l w r e of items cntained herein to such qualified review. Three copies of published articles resulting jmn the use of the requested …