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Dis tri ct Engineer Ymhattnn Di strict Cear Colonel Warren: Enclosod i a a summary of the oonf'arenca held in your office on 3 and 4 April 1945, as recorded by us. :Ye xish that you would study this and l e t U B know if it is essentially the conclusions arrived at. If it is not, please notify us of neceersary correotions. This document contains. Information affecting t h e nation.31 def in so of the United States ci:hin the In any manner to a n unauthorized person is crohalted by law. ,
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Conference of 3 and 4 April, 1945 on Rochestar Coniradt -2 Radiol. program con. ) 3. Determination o f effects of soft radiation, with reference t o the effects is to be continued as plarrued 4. Continuation o f 9r. Harvey's clinical fin g sr print stzldy 5 . Calibration of finger print zhanges under Dr. Harvey, using stonkeys as experimental animals. Here the effects o f Beta and X-rays are to be studied; it was not f e l t necessary to use Alpha rays. 6. Determination of minimum chronic exposure which produces no e f f e c t on This i s the experirofsnt which was discussed i n IZochester in January (1945) in which anisals, preferably rats o r mice, would be erp sed to chronic radiation ata low level o r levels and the deleterious eff0o.t; o f such irradiation be determinabt by *a mortality cumt38 rssulting from subsequent "acute" radiation as coxpared wit5 a concoatnitant 7. The following two experiments w e r e discussed and approved a t the January (1945) metin < i n 3mhoster but were not disaussed a t the meeting a t (a) Study o f factors affecting acute tolerance to X-rays. 3ffects of prophylactic and therapeutio prooedums on survival. (b) Exploitatfan of Bourospora as atool in detection of and oombating radiation effects. lend the xs elms to the analysis of radiation effect). (This organism has proporitas which Neutron experfmnt at Bewark was discussed and while no definite decision ~ 8 smade it seemed t o ba the consensus of opinion that this work would probably be extended so t h a t ana year's chronic exposure would be permitted. It was decided t h a t the pograln as prsvioualy outlined by Capt. Rekers on bone marrox transplants and bone marrow cultures should b e pursued.
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Conference o f 3 and 4 April, 1945 on Zochester Contraet -3 D. Cross circulation in irradiated oats (Lt, Valentine, with Dr. Lawrence This study is to establiah, if' psa i ble, the presenoe or absence of hematopoietic depressing substances oi roulating i n the blood following acute radiation. it m8 deoided, *et it should be carried on throughout the corning par as previously outlined in verbal discussions. This program has been discussed mpaetedly and It was agrfted that D r . Stern should plan t o do ths low dose ktacticmal ir radi a tim of ilrosophila in the next year. whether he can find an adequate replacement for Dr. Spencer, who will be This i s dependent upon cussed at some length 8s being undesirable. I have since taken this point up xith Dr. Stern and h0 feels he raay hs eble to carry out the experiment a t room bmperatures. It was decided that Dr. Charles' gsxstics program would brt terminated no new m a u ~ egenetics studies would be planned ?)ut t h e neaessary as previously planned and would begin tape15ng o f f about 1 September, 'top' personnel would be kept on t o complete a ompiling and analyzing of accumulated data. for Dr. Charles t o d e a survey of the matarrnltg. acd childrens' hospitals i n various parts of the, country, rrtakfng a study 0:' the abortions and the asked to conduct this study efter the completion of his present Er,eU0tiC6 It we8 further agreed that it would be o f advantage I t was requested that Dr. Charles be It was deoidad that #is work would be continued in the future as in the past and would consist al?nostmfitirb>y of k, Bale and h i s personnel doing work for the Dist rid t a8 requestsd. This includes several previously di8cussed tracer studies.
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Cunfereace of 3 and 4 A p r i l , 1945 on Sooheater Contract -4 1, I t was decided that Dr. Hodge would oamplote the aaute ntudiea on t h o r n compounds alrsady requested but not yet ooapleted, 2. Xo new f8eding experiments are to be start ad, to be carried on Por another year or until termination ( i f tsr~dnation is prior to July, 1946). Those already atarted are 3. It was decided that chronio one-year inhalation studies were to be carried out on the following oompounds: (4x0different concaatratiofis of dust a. The question of C23.6 was raised and it was deaided that gajor Ferry would investigata t h i s and would let us know whether w e would be requestad t o do a sinilcir ona-par ichalation study ?f this'cozPpound. b. In connoctian w i t h the inhelation program, the importance of knarring part iole size and the concentration o f the &st in the vat fw s # btS was emphasized, It wna decided t h a t Dr, flodge was to make available persatme1 to deterratae the part ide size of the various corapounds fn industry by whatever atethod or methodo he m y de-relog or may now have on hand, sad that the particle sire in tho dust expsri~sentrbare arb to coincide as closely as possiblo w i t n those found in industry. Apparently there f a no accurate inforacltioa regarding the concentration of the respective duets i n industry and Dr. Hodge, in oonjuIl0tion with Lt, Zowland, sill work outa satisfactory solution for obtaining these concentrations. and their ttmuport across the alwoofar meabrane was discussed. It was my understanding that D r , Ilodge uaa to aonduot suitable exper'mnts which wmild throw sane l i g h t on these partlculsr
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-5Conference of 3 turd 4 Rpril 1945 on Rochester Cantrnot 4. Analytical Ssctiora of Pherjnaaology Division It rraa decided that th6 .Analytical Seotfon of ths Pharrrurcology Masilrm No special budgetary arranpements were ta be arcLde far this but a masonablo amount of mrk could be dons as in the past. If, hmmmr, the occasion sliould c+rise Trhere t h i n work Became uereasonahle and +&e expnees of this work haitperad the m r k of the rest of the Project in m a p s c t t% budgetary allowances, the Diatriut would be notiffed and spci_&lallobimats-f or s pci al requests *&d be sought, " ape oid enalysea or services. The question of 1Xachanfem Studies was again brought up and it m u strtted by the Dist riot and understood by the labrbsrs of' the Whathr! lh it at i one which have been placed upon the Radiology and 8tituQnts of the normal individual uas disoussed. report t o an abstraat of the litma+ It was deoided to lialt-the Tt was decided that an average error of 25 per cent f
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ROCHESTER, NEW YORK Conferenoe held at Oak Ridge in Col. Varmn'8 off ioe, April 3 and 4, 1946 To dlacuea and outline the program t o be aarried':out either in oonjunction with or under the Contraot of the Manhattan Mst riot with the University of Roahester (Manhattan Pro joot). 1. Determination of chronio toleranoe l e v e l ~ . t oX-ray at.2SO and 1,000 KIP. It was decided that this study should continue with the following modi- (a>3 studio8 to continue for the duration of the Contract o r subsequent mnewals thereof, w i t h the exdeption that eaoh group of dogs be liraited t o 10. (b) Monkeys to be continued as at; p r e s e n t but no replaoernrnts be added, (a) Rata t o be continued as a t present until ' auoh time as the numbers ' x d be de ple bd eitber by radiation eff eot s or by natural cau8es. No replacements t o be made. (d) Rabbits t o be aontinued as at present until1 January, 1946. If at that tlnm they show no marked variation oompared ulth'other speoire of anilaals they 8 hould be disc on tin wd ; if' marked ohan@ are evident they are t o be oontinued. with referonoe to the lsnse and oornea of animals re to le rana a daaaer. (4,) It was requentad that we pay particular attention to the ayes This experiment is t o be continued as follows: the aoute mortality ourw on monkeys iato be completedj a similar oum for dogs iS t0 be -,-his document contains lnforrnatlon affecting the nationst detanso of the United Ptates within the -. 32. it; trjnzrniosion or Itin rcuelation cf its contents_ _ In any manner to an unauthorized person Is pro. hiblted by law.