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For The Period Ending December 31, 1956 INSTITUTE of NUCLEAR STUDIES UNITED STATES ATOMIC ENERGY COMMISSION P. 0. Box 117 Oak Ridge, Tennessee
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Chairman, ORINS Medical Division dyear report covers the entire year 1956. ng, it is a report orJy of the scientific work of the Hedical Did - Except fora amall. Cornfl the Oak Ridge Institute of Nuclear Studies. An attempt has been made t o itrate the report on material that is as yet unpublished, and alist of the omfor the year i s appended, e Medical Division i s organized in five subdivisions: a clinical proedical-physics program, a metabolic program, a biomedical program, and strat ive program. The report of the administrative program is not in-* n this report. Most of the scientific projects involve more than one of m strat ive subdivisions of the Medical Division. For example, the rarematerial is being reported by both the clinical and the metabolic subdiviKyker, chief of laboratory research, and i s reported by the personnel k of. t h e Medica Division. The basic work i s conducted under the direction kr hi3 direction. The clinical work, although dealing with the same subject 1-9 is reported by Gould Andrew, chief of clinical studies, and his colb. lhch of the work on the teletherapy project involves both the clinical
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Chairman, ORINS Medical Division This midyear report covers the entire year 195’6. Except fora small comment on training, it isa report ofiy of the scientific work of the Medical Division of the Oak Ridge Institute of Nuclear Studies, An attempt has been made t o concentrate the report on material that is as yet unpublished, and alist of the publications for the year i s appended. The Medical Division i s organized i n five subdivisions: a clinical program, a medical-physics program, a metabolic program, a biomedical program, and an administrative program. The report of t h e administrative program i s not included i n this report. Most of the scientific projects involve more than one of the administrative subdivisions of the Medical Division. For example, the rareearth material i s being reported by both the clinical and the metabolic subdivisions of the Medicd Division. The basic work i s conducted under the direction of Granvil Kyker, chief of laboratory research, and is reported by the personnel under his direction. The clinical work, although dealing with the same subject matter, i s reported by Goad Andrews, chief of clinic d studies, and his coland the medical-physics subdivisions and different portions of these problems are reported i n both sections. Much of the work on the teletherapy project involves both the clinical
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TABLE OF CONTENTS CLINICAL STUDIES, G. A , Andrews and colleagues ..... Page 1 METABOLIC STUDIES, G. C. Kyker and colleagues ...... Page 9 Potassium and Rubidium Studies .......,.. Page 15 Protein Metabolism ........,.,..,.,. Page 18 BIOHEDICAL RESEARCH, C. L. Comar and colle apes..... Page 21 MEDICAL PHYSICS, D. A. Ross and colleagues ....,.,... Page 35 TRAINING, Marshall Brucer and stdf.... Page &3 Not f o r republication without authorization.
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hn tin u ed emphasis has been placed on studies of alkaline-earth metabolism , with special attention given t o comparative calcium-strontium behavior. t t e r n of investigation has developed from intensive animal studies-designed w the r o l e of individual physiological processes-to more limited studies at i ents that help i n extrapolation of animal data t o nan. ready proved useful i n evaluation of possible health hazards from contaminadge will Serve a s a basis f o r studies of the mechanism of induction of bone and possible diagnostic and therapeutic application of bone-seeking radioIncreasing amounts of time and effort have been devoted t o training and cational duties, some of t h e more important of which have been (a) respomibity f o r biological aspects of Special Training Division's basic radioisotope chniques course; (b) responsibility f o r veterinary radiolo@cal health courses; development of biology kits for high-school teachers; (d) preparation of reon "The Biological Effects of Atomic Radiation" f o r t h e National Academy of fences; {e) supervision of foreign scientists and research participants; and editorship of a reference work entitled "Mineral Metabolism-An Advanced Trease," t o be published by Acadendc Press, Plans for extension and development of research have been worked out dong 1s t o bone-seeking radicisotopes inthe diet. of the biosphere with strontium-90; but from the long-range Viewpoint, this The rationale for use of strontium45 in tracer studies with patients, and irniWZ'y results of single-dosage experiments, were described i n the ORINS ear Report f o r the period ending December 31, 1955 (ORINS-l3). Attention has een turned t o t h e important problem of comparative behavior of calcium and tium i n man under conditions of daily ingestion of radiostrontium in milk. evious studies in this laboratory have shown that milk increases the absorption Urn as Compared t o calcium, both calcium and strontium, and also decreases t h e discrimination against stronThree patients have been studied s o f a r : a 72-year-old woman with cervical arcinom; a 37-year-old woman with ovarian tumor; and a 20-year-old man with leu- -a* The procedure was t o give a glass of milk containing tracer levels of cal-