Agenda of the Initial Meeting Committee on Isotope Distribution

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COZfZT‘i’EE ON ISOTOPE DISTRIBUTION 1. The persons who have accepted the Commission’s invitation to serve on the Committee on Isotope Distribution are given in The Commission desires the Committee t o : (a) review the general policies of the preserit Isotope.Distribution Program; (b) recommend future policies which will foster safe and effective use of isotopes, In addition to making recoinmendations on isotope distribution policies it i s hoped that; the Committee will also assist the Isotopes Division in its day byday problems of allocating isotopes.To this end it i s suggested that the Committee be divided into two working subcom;nj.ttces: (ID. parenthesis after each name i s the inajor field in which that person ’ s advice w odd be s ought. ) Dr. Brues (Lnirnal Biology and Radiation Protection) Representative to th a two Subcommittees.

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alternate who wocld servE: in case the regular member is not available for some reason. Dr. Evans believes thot the selected individual should bo a younger man who would work closely with the committee rrtember on isotope distribution problems and who would likely develop intoa high cc lib cr scientist capable of full filling a similar position in the future. i n view of the nced for future specialists in this fia ld and should be given consid ~ re tion. This suggestion has much merit T o guide the Cormittcc in consideration of its functions and the pro b lms of allocation pertinent parts of the l tomic Energy Lct o f 1946 fire given i n Lppendix B. It i s proposed that each initial re Qe st made for gk9-h use. of u particular iso top a would be rovimrod and rated by the four members of the Subc oinmittee on Huw.n Lp pli cations after the Isotopes Division has cxcmined the request for completencss The allocation of m te rials based upon the recommendntions o f the Subcormriittee could be handled in the following suggested a. I f EL request receives f-0-ur ~g-pr-ovf--1._s,,t h e Isotopes Division will promptly ul locate the requested material. for not t.11occi;ing then stor icl is given by the d is scn ting mitte d for re ting to the Sub corn it tee along with the views of the diss m ting necibei aida review by the Iso to pcs Division. will attempt to reso iv c the difficulties causing the two disapproval s and resubmit the request, along with e. summary ofthe modified s jt unti on,forE second rating. Eo allo - Division will inform the requester of the disapproval and will ettcmpt to of for construct iv a suggestions. of a request does not prevent there qu c ster from filing other re qu cst s for materials c.t D. h ter date.

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2. Requests for materials for uses not involving human subjects. a.In case only laboratory scale use isto be made of the material, it i s proposed- tho Isotopes Division: (1) Make allocation without reference to tho Subcommittee on General Applications provided sufficient evidence isat hand that the material will be used ina safe and satisfactory manner.* Such allocations will be reported to all Cam it tea members in the regular mm th lyre port (2) Refer requests to atleast three appr opr iata members o f the Subcommittee on General Applications when thore - quoats are oonsidered of a drub t ful nature, or when they would -be rejected, by the Isotopes Division. Selection of appropriate members t o review requests would be made on the basis of th z following fact crs : (a) knowledge end experience i n use of the requested - isotope,(b)familiarity with the field of app li co tion, and (c)ge or graphical proximity to requester. Approval i s dependent upon obtaining unanimous Rpproval o f the Subcommittoo members reviewing there qu cst. b. I n casu the mats rial is to bo used i n wid3 scale applications i n inrlustry, in agricultural field tests, or i n commcrcial products, it i s proposed that the request ba reviewed by three appropriate members of ths Subcommittec on Gcnoral Applications.Allocation of material will be dependent upon the unanimous approval of the rcviewers as w lias upon the Division. The latt cr hpproval will bo based upon informrition . gained by visits to tho locations involved. Subc omitt ee mamber sre qui red ? F. SUGGESTZD CRITERIA FOR TIXG ALLOCBTIOI~ OF ISOTOPES. 1. Significance of the problem investigated Under the original policies of the Isotope D is tri but ian Program, it was mc ess ary to evaluate the significance of the problem i n - vest i gated in order to in sure that the most significant problems would receive priority in obtaining muterial.. Now, however, i n the cas0 of most isotopes the supply appears t* be adequate t o meet tho legitimate needs of all requester s who can usa the materid safely. It may be proper t o remove this factor from the criteria governing tho allocation of material. In the case of uses which appear t o be unproductive, the Isotopes Division will

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2.. Training and/or experience for those planning-- - t o use material. Wider knowlodgs of the application of isotopes as tracers or ns therapeutic cgonts is increasing the number of people r e - questing isotopes who hsve had little experience in their use. Itis hence suggested that some minimum general requirements be adopted concerning the training nnd/or experience of those seoking all ocs tion, such as follows : e. A formEl intensive course in radioisotope techniques which includes background in radioactivity measurepents , monitoring and health physics. b. In lieu of a, above, threz months working cxperience ina * lab or a t or y ernp l oying radio iso to pes . C. fi knowledge ef radi uti on protection, such as developed i n t h e manual, Safe Handling of HfidioisQtopes, being prepared on Radiation Pro tuo tion. It is necessary to deterniina that the requester is equipped t o observe suf e protection practices and t o make satisfactory use of the material. The facilities required will depend on the radioisotopes employed, but selection of equipm n t from sach of the following categories is essential : (1) High encrgy beta emitters, such as F' 32 (2) Low energy beta emitters, such asC 14 and S 45 (1) High s ne rgy betri o mitter s (2) Low energy beta emitters (3) Gama or gamma-beta o mitter s.

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c.Shielding for beta rays and gama rays. d. Other equipment such as hoods, remote handling equipment, 4. Responsibilities of institution nl rind individual recipients of a. Regulations established by the Commission. The legal st nf ' f of the Commission i s proparing a set of re gu lzt ions based on the Ltomic Energy Bat of 1946 :ad recomniendutions of thc Isotopes Division. X sot of the b , Radioisotope committce for institutions. (1) Commit-tee should be required to approve ell request (a ) Nonmcd icr.1 ins t it u t i on (1) Atleast one Physicist or other scientific personnel fcmiliar with the problems of safe use and disposcd of' my tc rial. fLt lec.st two other investigators in t cras tod inthc use of mt or icl. (2)In lieu of a physician expcricnccd intho (2) f'L physic isn expo risc ced in detection cnd (4) IL physician experienced in detection and trez t mont of metcbol ic disorders. c . Thorough knowledge of Co mission rcpproved regulations,

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a,. Supply of requestod isotopes should be adeqw.te t o neet need b . Degree of hczerd t o which working personnel cnd gecerEl public would be subjected must be est cb li shed. Must consider general spread o f contominction.C . The Is o t opes Divis ion rec ommends forc ons ide ration the rat in6 L11 requests which receive positive answers on items 4&, b, and c would be cllocc..ted nat eric l on the priority indicated by the class It i s noted in Section5(c)(2), f~toinicEnergy h t of 1946 be distributed " with or without c$arge." Inthe pnst an effort 1ir.s been m de to fix the price of a vc il nbl em.te rials r.t such n level as would not be prohibitive to those workirg with limited research budgets but would, a t the efforts put into the production of thc mtc rials. Therc hsve been unly minor. objections t3the established prices quoted to rz ci pi ents of rr,.terinls. However, it i s cvidcnt th ct the1r.E.C. can rondcr cd d it ional cssist:.nce t o somc res c crc had thc rcp eu tic progrcms b y thosc 01: xry 1i::itcd budgets t o spend more mcacy on fcc ili ties and in st rur w nt c tion ad to cinploy cd d it ion c lhc lp for routine laboratory tr.slts, such c s monitoring. on sone invest ip tors torc is e spec id funds. Ccnsiderntion should be given to thc possibility of f rec distribution of This m y be especir.lly fcc sib le for the fic ld of cc.ncer res ecr ch inasmuch as the L.E.C. has funds which could be devotcd tocs sistance in this direction. It woiild ccs c the pressure I n view of the pos s it ili ty of some rr dio isotopes entering co mercia1 channels, the Committee m.y wish t o recommend bz sic principles of ap rio ing policy governing inrgo - scalo purchnse of isotopes by on indus tr in l and cc mie rc i alc or ~ c ~ rn.

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1.. RECOMMENDED TRAINING TO BE SPONSORED BY T€E AEC 1. Discussion of short intensive courses giving prospective radio iso top3users the fundcmentals of the tracer technique, instrument c tion and radiation protection. t o be directed toward qualified in vasti gators in all fields 2. Discussion of specialized courses for training people ofthe technicifin class as radiation monitors and surveyors 3 . Discussion of s pci aliz ed courses for M.D.’s desiring to employ rfidioisotopes as th map eu tic agent.s. J.. DISCUSSIOX OF THE ADVISORY FIELD SERVICE, ISOTOPES DIVISIO?’J* 1. Present staff : One radiochcmist and one healkh physicist. a. Preporntion of releases on up-to-date health protection b. Field visits to laboratories using radioisotopes. (1) Evaluation of facilities for satis f nc tory und safe use of radio materials,. (3) Recommendation on disposal problems in the field. le borat u rios using smsll 2nd medium qu n nti ties of rsdio - d. Consultr,ti on on rcdiochemical lub oratory construction 3.Add it iom lm d het,vicr demcnds will be placred on the service with the dev slop m nt of thG anticipated commercial and i n - dust rial uses. 4. Present staff inadequate t o meet the demands placed on it and to in sure reasonably s & f e use of rr dio isotopes in the field. Probably two a dtl it ion nl trained health - physicists snd another young chemist would be adequate f o r immediate

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normrLl and. moribund. For exnmplc, such isotopes IS: b . Usc of rc dio isotopes in pregnant women such as P32,I 131, Fe 55, Fc 59, and Ca 45. of specific wt iv it yr c quir cd). t o be c-dr-inistered to patients. 1:. Lnbeling of sprays, such 8 s D.D.T., to be br ccd cast by c . Use of Ca 45 in field - lining studies. d. Use of kr ge qunntit-ies of activity to inducc mt at ions in f . Use r:f long - lived rt - i dim atc rials in mets l tubes and pipos h. Uss of S r 90 c roth cr long - li vcd isotopes in lu nines sent C 14 i n pctroloum process product control. Radioisotopes in control of inking procedures md simi ln r

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Personnel ofthe Committee The persons who have 'accepted the Commission's invitation to serve on the Committee are as follows: Ga Fail la, D.Sc., Professor of Radi-.logy, Columbia University Medical School, New York.. Hymer L, Friedel l, .M. Di, Director, Department of Radiology, Lakeside Hospital, Western Reserve University,. Cleveland, Ohio. JaGa Hamilton, M. D., As soci cte Professor, Medical Physics Department, University of California, Borkeley, California.. .Joseph Wa Konnedy, Ph,D., Chairman, Department of Chemistry, Washington University, St. Louis, Missouri. o f Technology, Cambridge, Massachusetts Institute of Technology, Pittsburgh, Ponnsylvan ia. Austin Ma Brues, Id. D., Medical Director, krgonne National Laboratory, - University of Chicago, Chicago, Illinois. Leslie Fa ' Nims, Ph.D., Acting Hecd, Department o f Biology, Brookhnven National Laboratory, Upton, New York. of California, Lerkeley, California. Henry Borsook, PhaDa, Professor,Division of Biology, California Institute of Technology, Pnscdena, Cnlif ornia. PoC, hcbersold, Ph.D., Chief, Isotopes Division, Oak Ridgo Operations, Dr.Fn ill a has accepted tho chairmanship of the Comiittee and Dr. Aobersolc is to serve as Secretary to the Committee and LEC Liaison Representative.

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Atomio Enernv Act o f 1946 (1) D of in it ion - d s used in this Act, the term "byproduct material " menns any radioactive mter in l(except fission able mate riol)yielded in or mc.de radio act ivo by exposure to the radiation incident to the processes of * producing or utilizing fission nbl o material, or without charge, byproduot mTterial s to applicants seeking such m cte rials for research or developmont activity, medical therapy, industrial uses, o r such other useful cpp li cnt ions as my be developed. In distributing suah materials,the Commission shall give prefcrenco to applicants proposing t o use such materials in tho conduct of research and development activity or t o my applicant, and shc ll recall my distributed mterials from any appli - oant, vh ois not oquippcd t o observo or who fails to observe suoh safety standards to protect health as may bo established by the Commission o r who uses such mat c rials in viol nti on of law or re gul c tion of the Coinmission orina manner other than as disclosed in the app li cnt ion therefor.. The Commission shall not distribute any byproduct materials