Document text
Machine-read from the scan, so expect some errors. Lines that couldn’t be read are left out.
Page 1
MONTHLY HIGHLIGHT REFORT OAK RIDGE INSTITUTE OF NUCLEW STUDIES OFFICE OF THE EXECWIVE DIRECTOR The public relations representatives of ORINS sponsoring institutions will meet in Oak Ridge for a two-day seminar on May 9 and 10, 1963. to the invitations has been good. Official Institute visits will be made by Dr. Will ian G. Pollard, Execctive Director, to Georgia Institute of Technology a d to Emory University during the period January 8-11. sary celebration of Georgia Institute of Technology. Ethics at the University of Chicago January 16-1.8. He will deliver an evening lecture, Dr. Pollard will prticipte in the Conference on Radiation and Social
Page 2
Studies were started concerning a simple method f o r radioassay of feces opposed 2" diameter sodium iodide detectors i s feasible. i s adjusted t o "see" the garrnta rays i n the range of 150 t o 250 kev, the entire specimen may be assayed accurately with no correction required f o r sample can be measured with good statistical accuracy is about 1to 500 microcuries. This instrument can be built with ccxnponents already available i n the elecResults indicate thata two-detector system using If the spectrometer This system should work very well if the detectors are located 60 t o Using this arrangement the range of activity that resulted i n reconsideration of the track arrangement f o r the patient-transport system. Detailed drawings for the track have been procured frm the mUfaC - the cave through its ceiling plate; this gives us maximum freedom i n deciding how the air is t o enter the patient compartment and circulate within it. The blower and motor arrived and both 8,re free of radioactivity. The ventilating blower i s ne= t'ne ceiling, with the duct entering The Title1 proposal was approved i n Washington. Suggestions and annotated drawings were returned t o AEC-Engineering. designs f o r the patient compartment. The low-activity concrete has been accepted, although it is still undecided whether it w i l l be a "BurkhartVolunteer" mix (about 11 per cent of normal). Arm counter - Work is being done t o design an arm phantom f o r use i n running blank controls and dose standards. Whole-body scanner - The mechanical basis of the scanner isto be similar to that of the Ohio-Nuclear instrument. t o favor maximum realization of the instrument's potentialities. head, which will be very heavy, is to ride under the patient, and will use a photoscan recording methods will be available; they w i l l be semiremote, operated by a pair of Selsyn senders and two pairs of Selsyn receiving units. Modifications will be added designed During the past two months the Division participated i n a study of the This study is one of a series of experiplasma clearance of cobzlt-57 vitamin B l 2 i n three patients with chronic myelocytic leukemia i n remission. ments being done by D r . Leo M. Meyer of the South Nassau Communities Hospital i n patients with chronic myelocytic disappearance rate of intravenously administered vitamin E312 labeled w i t h radioactive cobalt from the plasma of such patients. These phenaena are attributed to the presence of increased binding sites for vitamin Bl2intie plasma of the leukemic patients, as compared t o ncnnal subjects. the plasma disappearance rate becomes as rapid as i n normal subjects, if the increased binding sites in the plasma of the leukemic patients are saturated by a large intramuscular "loading dose" of stable vitamin B before t h e injection of the radioactive vitamin. I n an occasional pa%ent with chronic myelocytic leukemia i n remission, a normal plasma disappearance rate for labeled vitamin B1,2 i s observed without previously administering a "loading" dose of the stable vitamin. The serum and psma levels of vitamin B12 are elevated I n addition there isa delayed I n the present study we found the disappearance rate of cobalt-57 ' vitamin B12 (0.13 microcuries of cobalt-g7) f r a the plasma of the three
Page 3
MEDICAL DIVISION - 2 January 2, 1963 "loading" dose of 1000 micrograms of Barker's coenzyme vitamin B12, and 24 hours after 1000 micrograms of hydroxocobalamine. Barker's coenzyme does not contain a cyanide mdical as does commercially available vitamin BL2 (cyanocobalamine) and may well be the form that vitamin B g occurs in the body. Hydroxocobalatnine is one of several analogues of ntamin B z that The experiment was then repeated twice-24 hours after a For each of the three p r t s of the study, I5 samples of venous blood were obtained between zero time and 48 hours. zero time to two hours were drawn through a short spinal needle using a placed in a plastic counting tube. A l l counting was done at Broakhaven National Laboratory in an automatic counter. The first 10 samples from Two milliliters of plasma from each specimen were # The Division received copies of the curves of the plasma disappearance rates obtained on the three patients before and after the administration Of ment are pending. prolonged disappearace rates for cobalt-57 vitamin B12 were changed to normal rapid disappearance rates after "loading" doses of the coenzyme. third patient had a n o m 1 disappearance curve before and after Barker's The results of the third part of the experiPreliminary results show that in two of the three patients In Bone Marrow Therapy and Protection in Zradiated Proceedings of a symposium, August 15-18,1962, Radiobiological Printed by Krips, Rijswijk (Z.H. ), the Netherlands, Nov. 1, Dr. Fred Snyder lectured on "Lipid Metabolism in Irradiated Bons Marrow" at the University or" Tennessee-AEC Research Laboratory. Dr. A r t h u r L. JSretchmar spoke before the Biology Club, Tennessee Polytechnic Institute, Cookeville, Tenn., on "Metabolic Effects of Irradiation