Cooperative Projects Between Donner Laboratory and Other Branches of the University of California

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Cooperative Projects batmen Donner Laboratory and other branches of the University of California. 1. Lipoprotein studies with the Pediatrics Department a t San Francisco for a year and a half regarding nephrotic children and children with errors infat metabolism. 2. Dr. Ernest Dobson with Dr. McCor@ in surgery here and i n San Francisco regarding liver circulation. 3. Dr. Jones with Dr. Van Dyke and Dr. Huff have advised ET. Biennan and Dr. Shimkin a t the Experimental Onecology laboratory on circulatory factors and methods of calculating life of ate cells. 4. Dr. Jones ha8 been i n constant touch with Max Kleiber at Davis, regarding the program on use of radioactive isotopes and techniques for using several of their people, namely Arthur Smith and Arthur Black, %&to have had training periods i n the laboratory. Others of their people have been free to come t o the laboratory with special as a source of help and inspiration for their program. Dr. Kleiber has flatteringly referred to Domer Laboratory 5. The Davia C a m p has been a source of volunteers for lipoprotein studies, essentially the entire faculty, and their cooperation has been excellent i n testing out possible agents for the improvement of 6. The Davis Campus has reciprocated by allowing us the use of large animals for circulatory studies and contemplated that m may use them in certain sem fractiona which are of interest in the study of lipid 7. "he Naval Radiation Iaboratory a t Hunter's Point has constantly drawn on our laboratory talent for assistance in their program during the been a lessening of intercommunication between the laboratories, but several of us are still being contacted frequently to help with some They have become sufficiently developed so t h a t there has

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of their research problems. aid some of us have given them as paid consultants, and this represents the time that has been spent i n our own laboratory on their problems.) 8. Projects with the Berkeley Campus a t large relate to materials which a r e procured by members of other departments which are now procured by The DOM ~Laboratory has still helped many people who need very small quantities of material d e n they are available from our stock, and we have helped people all over the University in an emergency when they have been short of necessary radioactive isotopes that we could loan I n the same -,on an informal basis, almost all of our special facilities have had their use lent to faculty members for reasonable periods depending upon t h e i r problem. This type of help Includes the use of the InfYa-red spectrophotometer, the special ionization chambers and the ultra-centrifuges. One department used our maas spectroscope fora short time and u till zed the exact plan to construct one of their machlne,but it did not satisfy their emc t requirements. been a request to use the developed metabolic ward (Chalkoff and Kinsell), but this is as yeta request that is Impossible to fulfill, (These remarks a r e in addition to any Biochemistry was offered the use of this 9. Franklin Henry has been granted permission to use the decompression chamber in continuation of work he had ccu?.ied out during the days of t h a t it may Involve S. F. Cook also. It i s possible that when this work materializes

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10. Relations w i t h the Biochemistry Department have permitted a constant flow of small exchanges of materials and help. ment of the coursein large molecules involving Dr. C o h n a8 a halftime lecturer have been terminated by Biochemistry, but there a r e satisfactory work relationships between Dr. Gofman and ET. Schackmn. Rodes Trautman and D r . Schacknw particularly seem t o enjoy an active exchange of ideas involving electro&SG techniques. ll. Dr. Calvin's group of organic chemists have supplied a large number of people including Kleiberls group a t the Davis Campus. 12. The Permanenta Foundation has been very helpful f o r several years. Since Dr. Moseley's work wtth us, we have not had a fellovahip that was s p l i t between Pennanente and Donner Laboratory, but we have helped them vith several problems of internal dosimetry and i n recent wants. Dr. Collim has extended fiimself to make independent assessments of clinical status of lipoprotein studies, and they have in addition supplied us with large numbers of serum specimens of m & q r types. The Highland Hospital, in addition t o our fonaal relationships for our own studies, has through Dr. Kinsell been i n constant touch with us for specific problems. Dr. Tobias, Dr.CoW and ET. Jones have been contacted by him several times during t h e past SF*months.

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1. With Professor Kleiber, Animal Husbandry Department a t Davis, on the subject of metabolic f a t e of organic compounds in COWS. 2. With Professor Hamilton Anderson and H. Ell lot at the College of Phannacy a t the San Francisco Medical School on the mode of action and f a t e of labelled drugs on animals and humans. 3. With the Division of Poultry Husba,nd ~ y on the Berkeley Camps on studies i n chickens of labelled acetate. 4. With the Virus Department on the metabolism of lactic acid i n 5 . With Professor Greenberg i n the Biochemistry Department on amino 6. With Professor Chaikoff i n the Zoology Department on metabollem of biological intermediates.