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Machine-read from the scan, so expect some errors. Lines that couldn’t be read are left out.
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2. ProJcct T i t f h : Instnunentation and Operation of l& Bo. 689 LAMPF Biomedical Facility 3. Budget Activity No.: 06-0248 I . Data Rwed : March, 1972 PI 1972 FY 1973 FY 197.4 11. Reactor Cozcept: Xot appllcsble. l2. Wteriab: Not applicable.
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of LAMPF Biomedical Facility LMWF has a dedicated Bioncdical Facility consisting of a beam channel for negative p i mesons and associated trcatmcnt and rescarch faci li tics. Thc scope of the work covered in this report is to in str ment this bcam channcl and thcn tosct up an o ~ erat iii ggro:~y, t o cover routinc opcration, maintenancc and improvctncnt of the facility. Develop:?cnt of a coaputer control facj lit!., mapping the pion bean and its mon and electron contaniinations and, i n gcneral, supporting thc program leading t o clir.ica1 trials of D i mesons for cancer therapy are all within thc scopc of this work. Two other meson factories are being built, one i n Canada and onc i n In FY 1974,funding for the LAYPF EioThis proposal refers tothe Switzerland. They shall both have biocledical facilities. \Vc intend t o keeg abreast of world-wide developments in this Jonain and derive every possihle advantage froa work done elsewlicre. nedical Facility instrumentation 3nd opcration will be supported 75% by the National Cancer Institute and 250 by the AEC. AEC portion only. - During this fiscal year, thc biomedical pion beam optics design will be completed as will the engineering design of the magnets \drich make up the beam channel. The cost of construction ofthe stubout for the Diemedical Facility is provided under thc UMT authorization while cost of the channel (Sl,OpO,OOO) i s provided by NCI. 2 . Channel Control System Detailed study of the channel componcnt - interface equipmentcontrol corlpi*Ler arrangement is started and will be iontinucd into FY 1973. Preliminary control computer programming is under way. biomedical pion channel presents agr cater challenge tothc channel control system dcsigner than do othcr LXIPF channels. there are unusually complex requircnrcnts on the corr cl at ions between the it ions, pion energy degrader thickncsscs, and patient position during the course of radiation therapy. All this implies the nceil for f3st acting and re li abl c control and monitoring functions inthe control system. In some respects the The reason for this is that 3 , Peripheral Devices and System There is a continuing cf fort to spccify and design dci7ices and systems necessary tothe operation of the pion channel. electrons utiich woilld contrvnintlte thc beam. The tar gc t should 3150 bc as a ccc s sib lc and as easily maintained as possible. order to attain an optimum combination of tliesc goals. This sturly will
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of LAII1PF Biomedical Facility continue as experience provides new information and as developing use of thc chcnnel dictates new rcquiremcnts. The best configuration of slits, collimators being studied atid pre lin in ary design will start during FY 1972. and beam stops is Be&! monitoring cquipmnt design is starting. Design of devices for monitoring pion flux, iiitegratcd flux contamination will begin. flux distribution and electron Shielding i s being designcd for protectjon of both the patient and the operating personnel. fiscal year and mechanical design of the shielding support ct ruc ture will The shieldinE cai cul at ions will be finished this S. Channel Tuning Studies Calculations aimcd a t determining the optimum magnet tunings for various radiobiology experiments and clinical situations wi 11 continue with the goal of cataloging a wide selection of tunings along with the resulting pion bcan characteristics. This is an inportant support activity nccesscry t o assure early and effective use of thc pion channel as it becomes Programs are being developed to calculate dose distributions for given pion bean range distributions. depth dose distributions to be set up relatively easily. Kith respect to thc ir LET distribution will continue into FI' 1973, These calculations will allow desired Thig cf fort plus calculations aimed a t characterizing pion'bems W . J. Slilaer became generally familiar vith current treatment This code will perform the basic calculations using a rela- - t iv ely crude model of the pion bcani. X treatment planning program for the CDC-6600 conputer A LAYPF research proposal cntit led "Tissue Chemical Analysis with blu-Msic X-Rays" was submitted t o the LAWF Program Advisory Committee and 100 hours of LXJPF bean tine w3s approved for the experiment. In ordcr to further study thc potentialities of this technique, possible applications of tis s uc chcini cal nn3lgsis with mu-mesic x-rays for i n order t o assurc that tlic most uscful mcnsurc;:,cnts will bc clioscn for thc Sucl1 r l i scussion and study will cont inuc:
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. Instrumcntation and uperation of LAWF Biomcdical Facility ACTI\*-:Y NO. 06-02-08 Final details of tlie pion channel will be complcted and will be incorporated into tlie magnet designs. supplies will bc conpletcd. In st nll a tic n of magnets and powcr Final design of the control system will occur i n FY 1973. There will be a major program of checking out the operation and interaction of the system components . The basic control feat urc s will Late in the fiscal year, the basic control system will grated with t h e channel components and chccked out. Design will continue on targets, slits, colli mat or s, bean stops Preliminary vcrsions of the various devices and systems ui 11 be and beam monitors. designed, fabric:.ted and cliecked out; a t t h e same time, design of additional and more sophisticated equipment will cont rnue. Basic beam monitoring equipment will be designed and fabricated. Shi il ding and shiclding supports wi 11 be procured, fa bricked and installed in the Biomcdical Facility. S. Channel Tuning Studies These stud ics will continue wit ; ,particular emphasis on specifying the channel tuning and beam char act cristi cs for bcms required for tlie early radiobiology and do sim try cxperincnts. 6. Dose Distribution Calculations These calculations will continue in close interaction with the channel tuning stud ics described i n Scction 5 . 7. Dosimetry and Beam Diagnostics Thcrc will bc Ra a j or effort, this year, t o develop and fabricate thc dcviccs and iristruncntstion ncccssnr!. for doing beam diagnostics on the beam channel and for doing the basic d0si;ilctry necessary for the carly rcldiobi ology cxpcrimcnts. Bean diagnostics and dosinictry mcasurcmcnt w j 11 begin.
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Instrumentation and upcration of LMIPF Biomedical Facility Preliminary cf forts will be madc t o & sign expcrinents for mcasuting LET distributions in the stopping region of pion beams, ment of accurate pion bcxi models. bccome al'ailablc for thc bioincdical effort in FY 1973; sone special hardware Kill be adJcd t o make trcatment planning easy on this nochinc. progran kill bc adapted to thc in t cr active environmcnt of this machine. An in t cr active computer (PDP-11) kill A number of alternative sets of mcasurements will be formulated so that the relative merits of each can be studied. Detailed experimental planning will bc done. Improvcmcnts on t h e channel expcricnce is gained inits use.- 2 . Channel Control Systems Completion and check-out of There will still be amjor by early this fiscal year. Kill continue td be made as more the basic control system will occur effort toward addinn both hardware and software features designed t o increase the flexibility a2reliability of 3. Peripheral Devices and Systems Design and construction of more sophisticated devices and systems moni to ring equipment and on the design of slits and collimators t o allow more precise control of the beam characteristics at the pst ici it. As detailed information is gained about the radiation environment inthe Biomedical Facility, improvenents vi11 bc made inthe shicldjng These stud jc s will continue but ata somewhat reduced lcvel from
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Instrumentation an rperation of LAMPP Biomedical Facility 6. Dose Distribution Calculations The developrent of more calculating capability will continue. The -phasis now will be on using input infonnation from basic dosimetry studies of pion beans stopping i n phantoms. These calculations will be closely tied i n with. i f not directly incorporated into,treat a ent planning programs. More sophisticated dosimetry techniques will be developed. There will be added emphasis on measuring LET distributions so that physical characteristics of the pion energy deposition processes will be available t o correlate with the results of radiobiological and clinical studies. use at the LAMPF Biomedical Facility. Work will continue i n developing treatment planning programs for Routine operation of the Facility will start in this year. Beam set up and check out, routine irradiation s and other activities associated with the programmatic efforts on the channel will be supported. covers operation of the biomedical channel for the time required for checkout 8nd for 255 of the beam time available for biomed applications. LASL grant request tothe NCI covers the remaining operations. Item 19. EXPENDITURES FOR MATERIALS, SUBCONTRACTS AND EQUIPMENT Consultants subcontracts and associated travel ; travel for Biomedical Users Group committees $35,000 Procurement of prototype detector systems and data acquisition equipment Standard electronic nodules Consultants subcontracts and travel ; travel for Biomedical Users Group committees $40,000 Procurement of prototype data acquisition system and detector systems -. 27,000
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Instrumentaton and uperation of WWF Biomedical Facility Elcctronic test equipment Standard electronic modules for data collection 3,000 Consultants subcontracts and travel: travel for Biomedical Uscrs Group committees $45,000 Data acquisition system an3 detector Electronics test equipment Standard elc'ctronics modales for nuclear data