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1. The purpose of this ox wr i ment was to deter nine : intestinal mdgs a i to - urinary tracts of a hupln rub j ect for a period of 40-60 days after an intravenous in jeo tion of approximately 5.0 q b t b. Tho qu unti ty af P. 49 presaat iz! the o irc ul r ting blood four hours after the in jeo tion. 0 . 'Ihs amount of t h i a ubstanoe whioh I8 deposited irr the pabllr and the epi php air of the tibia approx iu to ly 96 haarr after tho in jeo tion. 'Ba Fifty - three year old colored male was selected who was in an a ot mobile c ident and sustained the follcnring in juri er : a. Through ard through laceration of the tip of the nose and the lower clip and a superficial la mre tion of the kit nirt. b. Canminuted fr act x re of the left femur dnich was in good position. C. Conminuted fracture of the right patella which -8 5n poor position. d. Traarrerse fracture of the right rndiua and ulna which t.0 €n 1. The patient stated that b had always been in good health exoept ra chron io urethral diroharge which he has had for 10-15 years. Ho gave history of any kidmy or liver dir orders. 3. There *a6 nothing of note in h i r family history, The patient had always been snployed a8 a mnent mixer, 1. He was awell developed, well nourished eolored male with the above BEST COPY AVAILABLE
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EXPSRIMSNT I ON P. 49 4 4 &2. The other findings upon ex mi nation were: The edge of tkeri5ht pun il was irregular but reacted to li,qht and accomodation. The lens showed incipient cataract fo mati on. b. The patient had marked caries and pyorrhea. C. Bxamimtfon of the c h e s t revealod no abnormal fidings. Hi8 heart showed no enlargement t o percussion. quality and regular in rafe and rythm. T)le heart sounds were of good 3, X-ray eunnlnation of his chert was within noma1 limitr, but x-ray of hi8tnaer revealed marked a troph ic and hyper troph ic arthritis with osteochondromatosis of his left knee. 4. The laboratory firdings are as noted on the aocompnying 0h.d. 5. The only comments necessary are tht the specific gravity of the urine is uniformly lower than normal. The urines show an oocasional tram on the basis of chronic gonorrhea. The blood N.P.I.is r liz ht lye lent ed, and the area nitrogen is twice the normal vslub. All of this points to sohewhat dirninishad kidney functf m. There iea rear rent Dyuria of variable degree which may be 6. The patient ' s hemoglobin and ?3C wre lower than normal, and he showed a mild reduction of the total l!BC which mie tk re been produced by the sulfonamide therapy which was administered. There was, houever, no reduction inthe petoentage of granulocytes. 1. 100 cc of solution containing O.S% sodium citrate and 0.5% radium chloride in distilled rater was prep red and autoclaved for Fifteen niwter 50 micro li tars of P e 49 1 4 were a cu ur at ely renoved from an anpalo2. and delivered into a glass stoppered 25 cc sterile mllumetric flask. 5. 0.25 cc of tb above dilution n re removed with 0.5 00 tuberculim syringe through a 22 gauge needle. 4. The lsft median cubit al vein of the subject was entered with a sterile 20 gauge needle, and 0.25 cc of P. 49 14 were injected. Care m8 Wento avoid The syringe was not rinsed with blood. 5. The glass ampule -8 sealed a& returned. The solution in the 25 oc volumetric flash, the eyringe and the two IbeedleS were returned for asday, and assay and determination of the a chal amount of P. 49 44in9cted. mount introduced was 4.7 micrograms instead of 5.0 micrograns.