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ternally i s of g ~ 0 . i ~concern to the 8edic.l Secttoo. p h r a t r . Amounts lar#e emu& ta bo quickly Arthil pmduce $oath by blood dyecrbsi&m or po sri bly by bcute kidney Fnju-. Amun ts of r6di-a pert enougb t o produce doeth in a fer smnthe 8pptrontly do )o by dmage to the bloodtAcloqh ners too the dmhge to the b bod orgbns po b sk ly ~tedcxtlnetes. A t leafit 8itb ndiua, homorer, dorage too low to cau. doath by chmgcr, leading to death by cancer. because of chcngea of thir type produced, i e rttercrlfold lower than t h ~ t The dosbgr inom to be routinely Ira crusia& death by aore direct injury, ruch a@ h.r hen mentionce rbort. iag the dosade o f any &l.?hh-enittlng neterial nec ccm ry to ?roCuce acute dRD8ge in the h ~ nna ~ .The tine needed, howrer, to cury out Any Lori m of I cz pri a an tr which &re of the order of the lifetime of the expwiaental a-* x1a.l in durhticn t r conr:derrble; prot ably aeusxred in term of stny mnthe
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produced, when coapred with th lt pmduced by rtifim, rill tt eclltii, if tr!F Io order to Uko this calc ul rti on, it In aecesaary b ~ O T.I function of tire the a lr tri but lon in tho body, both of rao lus includtnp. ttr dbughtsr suC&tmcea, and of plutonium ormy ather dpha - es it tin F clesent for which ?ne r is he p to fleterraina the hacarl tft era b coq tion into the h ? y , hcve ac1 ~ rn t it a tir om etbd for catimating the amount of the olphr-actire elomont in tho bu b dy. of the above c&lcPlrtlons 8bdd be hornledgo ofthp acute and seaircuta o f being ot bin td by rtecorch grou ? ~r ee oc late c with the Lcdicrl Fectioa. Rocherter a thorough rurrey of the Utcrtture concerning the oet4bolicm of radim and radium poironlng, both of hums end erp rla ents l enintlr, i s beacute lethal bo606 of plutonltm rad polonlm. Uro, from a prellalncry rmeg
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oftho literature, i t remc prob ~ b l ot hat d&ta coneernlw ttrsua dlttributlon ptrimentt li r ted belor. Ucc 80 pap ore to check the qurntltatire methoce for pluto niu being der o lop d Dr. Elempelram and U g rsmclrtee anC, if c&rry out coacerubg the m.lrUoa botrtea plutonium content of the b d y and aiaount6 found la excrctt and blood rempler, wU1 be given dortr around thir polnt rl'zh ruff ici rn t ??read to deternine tke rgproximrte rbpo of the 10-1 e m * . About 16 of there nk riU bo tapt for Complete autopry and h e ~ to lo glca lrtndios .illbe eade o n about one-fourth of t be tem lmr lt, including several living at the end of 8 . Tracer std let with rrdiwn. Wenom hevc precise cusntitatirs aethode rrtflckle far rec ii u ccterainatlonE i n tlseuea by the radon escnrtlon aethod. U E Os ene it ive &.:?areapparrtur i e 12 almoet conttnwue - 0,q extenelre program rill mue nectegbry conrtruction of duplicate a2p.ratar. will depead to L certain oxtent upon o u r wrvey o f the Aitertture concerned The actual trrcer work done with red im mith rediua a eta boli ~ nand poi8o a in gb We tentatively propose, however, to car q out conplote tracer ~ tu dior,i aclu d iq balance experl~tnts, on rata kept
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thi eir be it g c8rrieC o n by other @roupr rasoclhted with the YcCtohl Ft c tion. ! I to do. 90 810 prttcularly interested ia as r qr of urine, kn6 ercmk en a aoa ~ u r tof 2lutoniun concentrhtioa i n the body. Also i t may be pre lb le,at come future time, bemuse of our brp it d ConnectlzmL, t a carry out kia it ed is to be ckrried out if a e : iblo, bec&ase of the pertinent in for a * t i ; . n 1% will ulva. t Thlr trtctr work with pluto nisa ic tentatively rcheduled for CL the .'ion G?LT r or k with pc tun in ereentillly comglete, and $'.e tracer wr i with radium is we:l der .8J, bo thet our roaerhht Limited personnel ritk wid? es3crlencs and skill ln ched s try will be used efficiently. Late available t o the Rocbeeter project lndicrte that dogr are coneidorably aero scnrltire to radioactire injury then rats, t o #e huasn in tu8 rerpect. We therefore gro ps e to carry experireate on dogo mi th the above eleatnts to the extont to and po bei bly CloPer out lethal dose which the damentr
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