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The committee had been asM la Sdvise t h Diviaion of Btology a d Medicine on the folloviag:
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edditional information a%out mutation rates i n mamala. The committee agreed that th- l a consideTa%leurgency i n obtaining of mice already M,l tuaa agreed that expassion of these s t ~ dle sshould l y adjusted am that l.esults from t k prograin can be obtaired in a mare reasonable (shorter) l e e of tfm. It is un6erstood that &a program ia designed to obtain infamatian on matation rates at apecific loci i n males at Zmer d o a q w (150 r and pasaibly 75 r ) than those previously used (300, 600 and IO00 r); t o inveetigate tbe feasi3ilit-j of p e ~ for n in gainilar studiee on mutation rates in females; to correlate ir rad b tion sensitivlty of cell8 in the @mu 11- at different stages in d.=w-elapment v l t h hietolo&cal cktsngses in female m i c e as has beendoEe with males; to cootmat effecta of chronic and acute trradiation; and to maerne mrall gelzetic dnmn&e i n populations. was the recommendation of the cm ltte e that t be mi on bere proposed should not curkil other program eupported 5 y A ! nor hmper the mCartaklng of or expansion in othsr f le lds of inveatigakim. tlcm that rbould be more actively &reloped in areer to obtain informtion necessary to estlnatlng gexzkic e-ects of em sure to ra2iation.
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-, (a) Mutation Studies: It would be admtageous to hhve G#~TB adequate data ralatfve t o a dosage threshold, or absence thereof, in the induction of matations by losizlng mdiations. Ts difficulty h obtaining material tommonly used. It should be possible to extezd studies to much (h) Populatloa Oenetica: Predictions of genetic damage i n future mmtiolls MYmnt be amde solely from measmmients of rates of mutation induetlon. D i r e c t obsacpatiorIu can bc made over a period of gereratlona in e-1must ba fahsn in e%trapolatlng fkorn observations on one specie6 to expected effect. In mother, and witbin the same qe cie s, from o m set of expriwsntal
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committee members a8 to how actively this program 8hoad coneemu0 seem3 to be that the research contracts already can be uxpected to uncover a number of beh~iarsdiffering A.om those already found in Rrosophila. It w a s suggested that uev research such as lonepvity, and &fee& of cbronic radistion, (c)Staes on HUIEW: TO extr ~ p ~ ate tlre results of animal experlmentatioa to expected geaetic effects of radbtion on man requires aome poiatS of r~f'eremeobtaintible only by direct observations on humms, Suah reierencc pink could follawing expasure to known amount8 d radiation, (3) masares of "aolectlm (1) spontaneous mutation rates, (2) rates of-mutation (c-I): be coaction of pertinent information ou m812was recognized to be au.emmoua undertaking, but, if at all feasible, should tie o m af the stsongeat interes.(;a of ATE. ~naddition to recognized in certain m a s for cooperative atudies which would include several group collect ix atondardlzed ata, A program mutation rates among cells in tissce culture should be actively B Up port abul d be all that i s required to get such studies under way, Ttoe possibility 02 deternlning spontaneous and induced Mecuaeiom k t h interested persons ond moaest fimncial