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OFFICIAL USE ONLY Advisory Committee f o r Biology & Ikdicine Staff of Division of Biologg & Ikdicine
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of the University of California at Los Angeles, and Director of the iitomic Energy Project, opened the twoday session of tb M ~ s o qC od tte e for Biology and Medicine held at the University ly introducing D r . b+ B, Dr. Stafford IJarren, Dean of the Ikdical School and thanked them for visit j ng the atomic energy project at the University. He spoke of the importance of the project and of its relationship t o the University and the Micd. School. Dr. hagher follawd Q introducing the members of the :1CBLi and the staff of the Divisim of BiologJ. and and its reletionship t o the medicd school, studies concern the use and application of reactor produced rdi?.tian f o r biomedicd purposes with particular emphasis u p the study and treatment of human cancer; the training of students hrad i a tim therapy and reactor techniques as they relate t o the field of medicine. He spoke on the plans for operating end maintaining a law power t n t e r boiler type reactor, together with a building t o house the reactor, adequate for the conducting of such act,ivit i e s. Dr. !Jamen presented his staff and thq smnwrized their individual Dr. Allen extended greetings t o the committee D r . Stafford Varren expleined the organization of the project He stated tkt the research
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Drr Tholnas Haley, Head of the Phamcology and Td colo & Divisi a, presented the first review by stating that his Division is concerned with general toxicology of an3miL.g; cm di ovas d & studies; pro teh dem tic n ; dust d is tri but im 3n rcspiratory tract ; effect of cfliq action on inhaled substances; pulmunaq lymphatic absorptions; particle size determination and b e dqosition. Dr. Thonras Hennessg follow d Q speaking of the vork of the Radiobiology Division which is invest imt bg effects of ionizing radiation in biosimple molecular sgstems t o &dies on the intact animal. Dr. Hennessy emphasized the studies of the Fadiction Metabolism Section and the Late These investigations range from simple studies an Dr. 3"ames &ad of the Biochemistry Divisian maine d its functims and spoke QXI the General lktabolism and Tracer Synthesis Sections and the work in Enzgme Chemistry and F%ysical Biochemistry. D r . Ralph Nusbaum of the Industrial Hygiene Division included in his remarks the work concerning problems associated with collecting Qamples of airborne particulate matter and in studying sam?jLes of particle size and the distributicm of such samples. Physics Section is responsible for Safety Regulatians and f o r pro,mr storage of radioactive materials. He brought out tbt the Health Also, f o r the instruction fn the proper handling of these materials and of the film badge dosimetry service f o r project personnel and around the laboratories. OFFICIAL USE ONLY
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Dr. Benedict Cassen reviewed the rrorl: of the IWical msics Sectian which covers hydro-dynamics t o medicine and biology on one @ and on the other the application of radiatian physics t o medicine and biologp. interest and support in studying the physiological effects of air blasts on living systems. Dr. Cassen is acting as advisor t o I&. Corsbie in cmnectian with the Test Series and is becoming familiar with the C i v i l Effects Test grmp blast and radiztim program. Dr. George T a m oriented the committee 04 the work of the Colorimetric Dosimetry Section irhich is a program trorked aut io collabomtian with the Chemical Warfare Service and coIIcems the msasurement of radi a tim with respect t o the diagnosis of radiatian bjq. D r . William S, Beck i n discussing the work of the Hematologg Section centered his remarks on the leucocyte. Their approach has been bioand leukemic leucocytes. The Pathology Section, headed by D r . Henrg C, Upham, works closely with the Gastro Intestinal Section of the Divisian of Pharmacologg and especially t h a t having t o do with the effect of irradiation on glucose transport across segments of r a t small intestines and the studies of Shay rat preparations. They have been chiefly interested in the caparison of normal D r . Upham explained various facets of work in progress,
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Nr. Kermit Larsm gave a very b te rest hg rep* on the Radio-Ecologg Divisim, which is composed of the S o i l - Plant rLeLationships Section, I.ktabolic His50ry Section, Eiological Field Survey Section, and the Dust md Parti date Section. questions concerning a mp which represented the lad Survey &e a t Almogordo in 1950 presenting the plutonium data on the s o u . The conmittee interjected with m y Dr. Andmw Dotrdy, Chief of the Fkdiology Division, and his staff oriented the committee cm the medical reactor. operatbg characteristics of the reactor and said that the contract as written between the AM: and the University of California wauld pdt the distribution of short lived isotopes which might be produced as a by-product of the reactor, subject t o Commission regulatian and in comflimce with the licensing requirements of the Atomic Energy Act of 1954, provided, hovever, t h a t such distribut9on and use does not interfere with the UniversitT research program. Dr. Greenfield presented the plans for the building which is t o house the reaMor and said that the cost of the reactor itself constitutes a very sma31-not insignificmt--but EL relatively small fraction ofthe total cost of the project. Dr. Greenfield thanked Dr, Bugher for his encouragement in assisting in obtaining the reactor and stated that without his help the project would not have proceeded t o the present point. He explained the design and
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Tour of UCLA Medical Center Upon the conc~usionof the oral. review of the progmn, Dr. Stafford Ilarren conducted the grdp on atour of the new medical center. thirteen acres of floor space and the buildings cost approximately,‘ Some of the unique features am the outdoor waiting spaces for out-ptients and relatives, the &door eating spaces f o r the cafeterias and the functional design of all units assuring a smooth flow of patients md materials with maximum usefulness t o patients) students and staff. The 14Aical School covers about The buildings are f ' unc tid as rrell as attractive. The Acting Chain mn convened the meeting of the Advisory Committee for the second day of its t w o day meeting. Biolom and ikdicine D r . Bugher opened the session by discussing the current activities of the Division which included a report on the proposed new medical center at Brookhven Nations Laboratory. He stated that the Bureau of the Budget had eliminated from the fimds t o be requested of the Cangress by the AEC those for the construction of a nev medical center at the Brookhaven NatioaaL Labomtorg for, according t o budgetary assumptions, there was t o be no public trorlss program for the Fiscd Year, 19%. over this curtailment of fbnds. The Cdt tee expressed great cancern A broad discussion ensued. They felt OFFICIAL USE ONLY
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that the present hospital at Broblchaven iSa potential fire bad and it is danger- t o house pti ents therein, and mder present conditions, it is difficult to obtain and retain a suitable medical staff. k this connection, the following mtian was &e by D r . Doisy, and unaninaausly approved: The facilities are inadequate expediausly as possible - that nev permanent type hilikings are needed and ire urge that funds be appropriated f o r this puTpose.lt energy, and of the strides made in the advancement of the program. t o l d of his acceptance of an invitation from the World Health Organization t o attend a meting in Geneva (December, 1954) as a represefitative of the United States t o discuss medical and public health problems, together with representatives from Canada, United IClngdom and Belgium. Dr. Bugher spoke cm the proposed preparation of the agenda for the International Conference and said t h a t the present abnda covered parer reactors and isotopes end that the applications of atomic energy t o biology and medicine had been omitted. be discussed a t the next committee meeting, specificnlly whether two conferences should be held - one f o r the reactor program and one f o r medical and biological applications. Continuing, Dr. hgher spoke on the International Program f o r the Pesmtime Applications of atomia He suggested that the problem OFFICIAL USE CNLI
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Jaw ese Conference of Dr, Pearson, e t al, brought out the salient a ccm is hm ents of the hwese conference vhich vas a direct autgrothh of the BII(lN1 incident D r . Bugher in advance of the &?turn from Japasl and also largely out of the visit that Drs, Boss and Danaldsan mde in connection with the f i s h problem in Japan. The conference vas jointly sponsored by the Japan Science Council and the AEZ and vas more successrul than anticipated. of the fact that this group of Amricans had traveled so far a d had brought so much information. of m relationship with Japan had been altered. program at the University of Tennessee farm at Oak Fidge. reported that D r . Staban at the instance of the Division of Biologg Dr.hgher reported an the administrative problems associated with the operatian of the research and Xedicine had visited the project recombuded that should be patient with the University and tryto assist them in obtaining atop qdity person t o direct the project and t o oontinue it under the management of the University persannel. The committee reviewd the program and activities tendency t o give under-emphasis t o gadgeteering in the electronics field whole than my other, be bdlt up i n each one of the individual projects. appcrently less coordination of this aspect of the program as a He cautioned lest an instrument development section
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Dr. Fail& thought that at UCU considerable ori dnd it y had been in attacking mud problems in in s trm nt ation. h connection with the study of the problems peculiar t o UCLI, D r . Stern suggested that it might be well. t o arrange for an exchange of scientists who have been at AlX projects or laboratories for several years. rotating policy might stimulate new thoughts and programs. D r . Bugher is planning t o have the matter explored by the staff of the It was the sense of the Committee that there i s not any other large TOj e c t that has achieved the jntinracy of associatian irith the university as this project had with t h e University of California at Los hgeles. Note After the luncheon break a visit vas xmde t o atomic energy projeots. of loyalty of ’ princiwd. b vest imt or Research Division of the Interagency Group studying unclassified research contracts from the standpoint of “Layaltg of the Principal Investigator.tt The committee uas impressed with the policy now in effect at the Natimal Science Foundation. Hoirever, in connection v i t h AEC grants, the committee believed that the present policy should be continued - t h a t there should not be a regular name check of principal izlvestigators an unclassified contracts at reputable Dr.. Dunham reviewed the report prepared in the
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Report on ststus the cmtents of the report wuch fncludd tables and charts. The Conmittee interjected many questims pr tin ent to the problem. (Cop of July 1, 1954, an Project w m . He explained September and October, 195.4, takm an Primates both by the U.S, Public He He .spoke of a planned conference an Wse of Fadiation Effects on Aging.11 done in long-term studies whether you use radiaticrll as your experimental e and the AEC. The goal of the ce is vhat can be tool or whether you are thinking strictly in terms* r,I >of the natural aglng process o r other things that might affect age. -.,a<, Dr. Doisg and they wem approved ~ nan body ; read, a motion made D r . Burnett that they kk approved was seconded by
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the first day at the Universiw of l?ashh&an in Seattle, \lashingtan, January 13, 1955, and a two dag meting a t the Hanford Operatibs Office, ad t o hokd a th~-0 day meting; Ibpression of thanlss \ Jam and his staff for their gracious hospitality A vote af thanks was expressed toDr. Stafford mittee & ' opp rt unity of meting at UCLA and of seebg the medica and me c&ttee went in toke c chairplan, ACBi.1 m e Ccmxnittee appoved unanlmOudy a notian d e Dr. Stern, seconded kyDr.mett that Dr. Fallla should be asked t o serve\ as Chair mn of the ACE1 t o replace Dr. Elvln Stalnnan whose appointment termhated on June 301 1954. Likewise, upon a notion made by Dr. Stern, seeded by D r . 3;upett and approved unanimously, t o have Dr. Shields Warren contlnue t o serve as D r . Jcsnas Jergen Christensen was presented. It tias the Sense of the Cormnittee that it would be well t o consider other persons at the W e A discussion was held an names of persons for
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time before a definite codkment;.-iS de. Names ok other nominees vill be presented at the Janmq meeting. Ad jmerit The methg adjaurned at530 P. 14. DOE ARCH Um