Minutes Advisory Committee for Biology and Medicine Sixth Meeting Held at Atomic Energy Commission Building 1901 Constitution Avenue, Washington, D C, February 14, 1948 (AEC-Acbm 6)

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-Advisory Committee for Biology and Medicine The sixth meeting of the Advigory Committee for Biology and Medicine ofthe Atomic Energy Commission pasture at 9:30 a.m. atthe Office of the Atomic Energy Co mission, Washington, D, C. Present at the meeting met with the Committee until 1:OO p.m, and Lfr, Lilienthal assumed the chair. Members of the staff o f the Atomic Energy Commission were present at various intervals Thompson, Mr. Llorse Salisbury, ab.. 3ohn Martins, Minutes of The minutes of the meeting of December 15, 1947 were December considered and the following addition made: 13, 1947 I n view of the suggestions made at the meeting o f the Advisory Committee for Biology and Xedicine on January 9, 1948 that a discussion be included inthe

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8*1.11D is tri but ion Co ittee, it i s recommended that the following material be added tothe rnihdtes of that "On October 30, 1947 it was announced that the Interim Advisory Committee on Isotope Distribution Policy and two subcommittees wished to resign. Their resignation was rec dived with regret. a new committee on Isotope Distribution was proposed: Gioacchino Fail la, D. Sc., Professor of Radiology, College of Physicians & Surgeons, Columbia University, N e w York, New York. University, Cleveland, Ohio. Directed Operations, Atomic Energy Commission. Physics Department, University of California, Chemistry, Yashington University,St. Louis, Missouri, chu sett s : & st it Ute of Technology, Cambridge, Mass. Laboratory,. Carnegie- Institute of Technology, Pitts - burgh, .Pen,nsy lvan ia. Labora.tory, University of Chicago, Chicago, Illinois. Secre.tary t o : the Committee and Liaison Rap rs sent at ive. o f the Atomic Energy Co kiss ion, California ; . Berkeley, Calif of nia. California ' Institute of Techno loa, Pasadena, Calif. Brookha,qen National Laboratory, Upton, Long Island, "It was suggested that Dr.Fail la be appointed Chairman of the Committee. "The proposed functions of this committee would be t o aid the Cominission in establishing new policies on the distribution of radioactive mata r in ls and t o review from time t o time existing policies.

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compose a subcommittee on Human App li cst ions who will review all initial requests for radioisotopes to be used ex peri me q tail y or othervrise i n human beings. Subsequent requeSks ofa given user for the same ,purpose will not be reviewed. and Bdrsdok will >bm$oso a Subcomntittee on Allocations hnd Distribution and will review doubtful requests for radioisotopes to be used i n fundhmental and applied research,tho field of education; industrial app lica - tions, and commercial ef it c rp rises r "The Isotopes Division will assume responsibility for other allocations of isotopes. Because of tho exper'icnoe obtained during the past year and half of the program hkld the initiation of a field service on isotope techniques, the Division is well qualified to handle this responsiThe minutes of the meeting of Jznuary 9 & 10, 1948 a t Los Alnmos, were considered and approved. Public ct ions of the Division of Biology and Medicine : ferred with the Committee and out lina d the publications being issued by that division. The desiro of the workers in biology and medicine in the region cl laboratories to have up-to-date information of tho activities in parallel and related lines to their own was discussed, nnd it v~as felt that some mechnnism should ba doveloped whereby a technical bulletin could be prepared and circulated, Dr. Thompson outlined various possibilities ar,d also stated that such a publication would bo entirely faa sib lc. prop a ration and circulation of such 2bulletin in the Division of Biology and Medicine would be acceptable to

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nh is division. Dr.; Xearn stressed the value of bulletins such as wipe issued by the Committee on Xedical Research during the Yar and stressed the importance of the in it i ad tion of such a bulletin as soon as possible. Dr, Thompson stated that a similar journal had already been prepared in the field of metalldgy and deramics. Dr, Thompson suggasted thst such a bulletin might well be made available within the A to mid Energy Comtnissioh installations concerried with the use of isotopes a8 Well as t o those investigators holding contracts with the Commisshn and to the Library of Congress and associated 1ibrarie.s. Both Dr. Bronk and Dr, & stings emphasized the disadvantzge of est ib li shing a formal journal under Atomic Energy Commission ru spices,but indorsed the technical bulletin proposed. XI-. Faymrck suggested that as u mary of pertinent information on the bio logic and medical as pacts of atomic encrgy might well be prepared perhaps by coritract. Dr, Stakman mowd th st the committee recommsnd that there be two types of publications, one a bulletin of declassified material in the field of biology and medicine t o be given as wide distribution as the exigencies of the case require and second, e. technical bulletin of the "House Organ" type be established also; and further that thc committee Igo on record as being a t the present timz opposed to establishing a new journal to

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be printed and distributed like rc gular journals. Motion seconded by Dr.honk and cz r ried unanimodsly, The Committee then considered the various res z arch contracts pre sata d on the Agsfida, Information was presented regarding contracts be in sen the Offics of Sahta Fe Directed Operations and the Medical Schooi of Was':ington University.A contract has been nrranged:in the amount of $29,500 for8study o f "Nucleic Acids in Organisms Exposed to Ionizing Radiations," A second contract calls for the oonstruc? tion of special ultraviolet optical equipment for study of "Radiation Eff mts on Cells." This contract is for $45,500. This ' lcd to a discussion of the relationship of Tashington Univa-sity t o Los Alrmos Scientific Laboratory. The ssr vices given.the laboratory by the staff o f 'Washington Uni vw s it y and particularly ilx medical school were fully discussed and gratitude expressed for the help rendered, It.was felt that in view of the general policy of the Commission i n regard to regional laboratories that it was unwise to establish special relationships between Los klamos Scientific Laboratory and the %shington Uni vcrs it y Medical School. It was further felt inadvisable to construct on the grounds of Kashington University a laboratory building for the implemGntation o f such a n agroement. The offar of Dr. R. F. Moore in this regard was consequantly daclined with thnnks. DOE ARCH IV S

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The following research contracts to be implemcnt3d under direction of tha Office o f Naval Research were then considered and the following actions taken: Co1l e gc Stakman and seconded by Dr. & stings that the Committee approve that the Office of Naval.Rosearcsh be notified that funds inthe 2mow.t of $29,500 are available for' one yeat beginning July 1, 1948 for the support of a research pro j z ct at Unioa College i n cooperation with General Electric Research Laboratory, Schenectadyd New Effect of High Voltage Radiztions," with the proviso that khe project ba strengthened with regard to obtaining accurate physical mcasurements, This motion was carried Tufts College Hedical School 1 Pr, David Rapp0r.t: unanimously that th s Advisory Committee for Biology and School Xedicine approve that the Office of Naval Resaarch be notified that funds i n the amount of $15,000 are available for one year bsginning July 1, 1948 for the support of are s mr ch project at Tufts College Medical School by Dr. David Rapport an titled : "The Effects of Radiation on Reactions Associnted with Growth."

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University Dr,Hastings, and seconded by Dr. Vearn and voted unanimously th nt th a Advisory Committee for Biology and b di cine approve that the Office of Naval Research be notified that funds inthe amount o r $11,400 are available for one yew retroactive to 15 January 1948 for the support of rose arch .projects at Howard University by Dr, Hcrman Branson on University University of Illinois - Dr. Louis Kidenour : Moved of by Dr. Beadle, seconded by Dr. Stakman and voted unaniIllinois. mously that the Advisory Committee for Biology and Xedicine approve that the Office of Naval Res j arch be notified that funds inthe amount o f $3,000 are mail able for one year beginning April 1, 1948 for the support of a research project at the University of Illinois under Me harry Meharry Medical College - Dr, Paul Hahn: The Med ical program for the treatment of neoplasms by direct in fil tra - College tion of radioactive colloids at !&.harry College' under dir cc tion of Dr.Paul F.Hahn was fully discussed. The fact that a strong clinical group had been developed a t Pkharry Xedical College w.s outlined by Dr.Goodpnsture and the advantrge of this to the prcposed progrcm was stress od. It wzs felt that tho total amount pro j oct ed

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could not be wis c ly utilized in the first year. Movsd by that the Advisory Corn it tee for Biology and Medicine approve that the Of ' fide of datthl Research be notified that funds inthe amount of $50,000 are available for one year beginning Idarch 1, 1948 for the support of a research project at hlehnrry Medical College by Dr. Paul Hahn entitled : "Radioactive Gold Colloids in Treatment of Neoplasms by Direct Infiltration. " This approval i s contingont upon the.-appointmsnt of as rt is factory medical Mas snchu so tt s Harvard Dr. Vearn, seconded by Dr. Stakman and voted that the Peter Bent the Office of Naval Research be notified that funds i n Massachusstts Institute of Technology - br var d Medical School and Peter Bent Brigham Hospital : Moved by Advisory Committee for Biology and %di cine approve that the amount of $73,650 are available for one year beginning July 1, 1948 for tkia combined progkam of Harvard University Medical School and Massachus.?tts Institute of Technology and Peter Bent Brigham/on the " Certain Nedical Aspects of Atomic Energy." were absent from the room'during this consideration. Kett c ring by Dr.%stings, secondjd by Dr. Stakman and voted that Ins ti tut e the Advisory Committee for Biology 2nd i,&dicins approve

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that tho Office o f Naval Research be notified that funds inthe amobfit of $40,000 are available for ono year beginning July31 1948 for the support of aras z arch "Studies of Distribution of Isotopes i n Dr. Bronk, seconded by Dr. Wearn and voted unanimously that the Advisory Committee for Biology and Medicine approve that the Office of Naval Research be notified that funds inthe amount o f $9,800 are available for one year beginning July 1, 1948 for the support of are sz arch project at V!ashington University by Dr. Jamas Kolan ent it lod : in Colloidal Form as Therepeutic Agent i n Carcinoma." "Use of Gamma Ray Emitting Radioactive isotopes Chanutin is Professor of Biochemistry at the Uni vms it y of Virginia and has been engaged in studies on the " ' Distribution and Chamical Changes of Proteins on the Plasma nnd Tissues in Normal and Pathological States in Research Animals and Human Beings." He is at pre smt working on research contracts from the Chemical Corps of the United States Army and from the Office of Naval and Tissue Protein Fractions " i n nnimals and patients

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-who. have been exposod to varying doses of radiation for varying periods of timsi The work wotfld be carried out originally on rats. IAovcd by Dra Bronk, seconded by Drr Beadle and voted unanimously t h n t the Advisory Cpmmittae for biology and I hdi cine approve that the Office of Waval Research be notified that funds in the amount of $25,000 available for one year for the support of a research project at University of Virginia by Dr.Alfred Chanutin of Missouri is for a small grant to support a problem on the translocation of mineral substances in plants, This would include i n what tissues they are moved, what the mechanism of movement is, and what rel at i oh ship it has to other physiological processes, Movement would be followed with Geiger counters. Moved by Dr. Hastings, seconded by Dr. Stabnan and voted unanimously t h a t the Advisory Committee for Biology and Nedicine approve that the Office of Ihvnl Research bc not if is d that funds in thz amount o f $675 are available for one yenr beginning July 1, 1948 for the support of are scar ch project at the University of Mineral Substznces in Plants " subject to aLpprov2.l of the un ive r s i ty. - 10 -

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suggestion of Dr. tlhlmann of Michsel Reese Hospital that a contract be undertzken with that hospital to build a 35-40 million electronvolt beta tron for bio logic and medical purposes was considered. After discussion it was felt that the offer of the Michael Reese Hospital t o undertake this contract should be declined in light of the fact that in the Cancer Program it i s planned Co provide such facilities at the regional laboratories where it will be available for the use of qualified investigators on the staffs of the cooperating un iver - si ties and their associated hospitals. Ke tte ring institute that it undertake a contract in the' amount o f Institute $8,590 t o support the work i n the field of antibody studies was discussed and the offer to undertake this The commissioners then met with the committee and lined the interest of the commissioners i n the work o f the Division of "iology and Medicine. He stated that it was of great importance that the pcoplc as a whole have a clear idea of what the commission ras doing i n status of tho Cancer Program and thera was general

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Pro gram aspects : First,the provision of facilities at the C,atlcer Pr&p'+tnl This progrnm consists of four regional laboratories for clinical in ves tight ion of the value of tho different materials and energies under the control of the commission i n cancer treatment and cancer research, Such facilities should be operated as research bed t o be made available to qualified invest i - gators from those institutions associated with the regional laboratories. It was felt that the number of beds should be kept s ml1,preferably not over 50 i n any one institution, and that every precaution be taken t o prevent those beds from being used for routine cars, To ' implement this first step, beds will be nade available d t the Oak Ridge Hospital and at facilities provided a t the other regi oral laboratories. There was a full discussion of II proposal that there be established for the Argonne National Laboratory in conjunction with the Gold blatt Cancer Unit a 40-bed canoer research institute with appropriate laboratory facilities ; the hospital to be administered by the Lledical School Fli nics of the University of Chicago, and its facilities to be available …