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TO : Commissioners and Division Heads FROM : Carroll L. Vilson, General Manager SUBJECT :. Meeting of the Advisory Committee for Biology and bledicine The eighth meeting of the Advisory Committee for Biology and I edi cine will be held April 23-24, 1948 at the University of California, Invitation is cordially extended to attend this meeting. 0F1, Consideration of the X nute s of the meeting of Karch 13, 1948. 2. Report on the Fellowship Training Program A. Membership of National Research Council Committees. -.- Homer N. Smith, Chairman, Professor of Physiology and . Director of Physiological Laboratories, New York University College. of fledicine, Eew York, N. Y. Austin :.i. Brues, Associate Professor of iiedicine, University of Chicago,. Chicago, Illinois. University, Mashville, Ten ms see. Hper Louis Friedel l,Professor of Zadiology, stern Re se'rve Unive r s ity, C leve land, 0h i 0. Joseph G. Uamilton, Assistant Professor of Xedicine and Radiology, UEiversity of California, Berkeley, Calif. Roy 2. Eracke, Dean, School of Xedicine, University of Rlabana, Birmingham, Alabama .
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(2)Pre doctoral Fellowships i n Biology C' / Stanford University, and Dean o f School of Biological Sric G. Ball, Professor of Biochemistry, Harvard Medical School, Boston, i lassa chu sett s. J. H. Bodine, Professor of Zohlogy, University of 3 Iowa, Iowa City, Iolra. oward B, Lewis, Professor of Bia logical Chemistry, nd Director of School of Tharmacy, University of ichi gan, Ann Arbor, Michigan, biology and Biophysics, University of Chicago, (3)Postdoctoral Fellowships in Biological and Agricultural R. F. Gustavson, Chairman; Chancellor of University o f Nebraska, Lincoln, Nebraska. fi' ' Research Foundation, University of Per n sylvan i a, ' A G. Evelyn Hutchinson, Professor of Zoology, Yale University, New Haven, Connecticut. sity, and Director of Mew York Botz n ical Gardens, (1) North Cz ro lina (a) Boyman G+hool of Izedicine, Wdce Forest College dormofial acd Tharmacological Actions on the Formation of Tissue Phospholipides" f o r
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Bolaman Gray School of Medicine, 'A'akz Forest and Turnover of Sodium and Potassium i n Acute Infections " for one ycar beginning July 1, "Mcasurement of Volume of Flow of Blood i n the Eidney and Level of a n Unanesthetized Man by Mems of Rz dio isotopic Procedure - $5,000 Relaxin Extract of Corpora Lutea on Blood and Oak Ridge National Lz b oratories - I n August goods Hole ( 6 Follows) - In July md August Brookhzven Ik tion c lL zb oratories - In July 1948 D. Training r t Columbia University in Bio:>hysics There is a possibility tl xt additional need d spnce may be provided by alterations in an existing building now being used largely for stor ngc pur pos ~ s . will be explored further by Dr. G. Fail la. It i s believed that f nci li tics cnn be provided ivithout additional all oca - tion of funds t o make possible the training of a substantial number of fell ova in this important fiold. 0 /' develop the set rz in ing facilities. 9. Larrruncc and Robcrt s. Stone.
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refers t o work with radioisotopes,(zicc,iron,iodine, There is a question as t o how much ~ , & ~ " Health Service and Atomic Lnzrgy Commission). t!r. Fitz - patrick of the Office of Mavzl Res2nrch will look into 4. Report on Support of Research Projects Individual Cells in Available Body Secretions,i.e. Oral and Vaginal, of Animals Subjected t o Deep Therapy X-rays" effects of Radiation from Excessive Amotmt o f 1-131 i n the Organism, and Various Physiological Fhenomena and Elvents Studied w i t h 1-131 as a Tracer"- $3,550. _ _ of Dyspnea and Disability inPatients with Chronic 5. Research Projects for Committee Consideration "Radiomedicine Research": A total of $104,250 was included under this title in a L!assachusetts Institute of Technology general request for funds to Office of Naval Research, amounting to about $1,000,000. The Office of Naval Research has referred this part of the request to the Atomic Enerey Commission, Division o f Biology and Medicine.
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this matter and no recommendstion i s made at this time. The amo-mt requested is $66,500. Part 11, under Dr. J. G. Trump, refers to (1) Cancer treatment,(2)E act eric i dal effects, and (3) Cathode rzy induced chemical and physical reactions. should not be divorced fr on hospital facilities, which a t present are not available at Massnchusetts Institute of and czthode rays is of interest to the Division of Biology The total amcunt It is felt that cancer treatment The work on the b acts ric i dal effects of X-rays Itis recommended thnt $15,000 be made avail zb leto the Office o f ?lava1 Research for support of the part of Dr. Trump's program r elz ting to the b act eric i dal effects o f X-rzys and cathode rays and ' close fy related problems. Clinical Investigation upon Vrrious Aspects of Chronic Pulmonary 3is e as c 15nnifested by Persons Associated with the Industrial Production 2nd Use of Beryllium mdits The Trud mu FoundAion is correlating its research work with that of the UnivGrsity of Rochester group i n the ficld of beryllium poisoning. The approach at Sr-ranac i s
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largely concerned with the development of the dist ,=qse i n its chronic form inthe experimsntal animals, This i s of major importance 3s there has as yet been no development of the chronic form of the disease in a large number of species treated with beryllium alone. Dr, 'irorwald s research will involve synergistic eff s ct s of lung irritants and lung infections with bdryllium. is still one of major importance tothe Commission, This project has not yet been completely clarified,but it i s owing tothe overlapping of the Office of Naval Research grants in aid and some phases of the projected research. Dr.Shilling,Dr. Vorwald and I arc resolving this point. It i s recommended that the research pro j act of the Trudaau Found - tion on beryllium poisoning be approved i n principle subject to final clarification by the Division of Biology and Medicine and the Office of Naval Research. Rapid progross i s being made in this Ciield, A panel 2h a s boen consisting of E. 3 . Lamonce, Iwill be i n very close touch with this.H milton,Stafford mzrren and others will be brought in2s expert witnesses. The I.li1itx-y Liaison Committce 7.411 sp point a group of
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represent z t ives to the panel. of the Chemical Corps c t Chicago isto be continued for Tha Toxicology Laboratory several months, particularly for aerosol work, until such time as the panel has evolved a definite program. Close I liaison is being maintained with the Chemical Corps. will probably be Chairman of the Panel, tvrenty-five million curies pt3r square mile will be required t o render an area untenable for periods over one o r two Mc ban will be the It is estimated that approximately idr, R. J. Ropley has been appointed as Director of theI Civil Defsnse Tl rn ning df the Office of the Secretary of carried on. Colonel Boers has been the liaison with us. Th,? organization of this unit is being Atomic Energy Commission has expressed interest in this /'(a ? field and expressed their willingness to help. An organi- >3i3yz nt ional me ding of the various interested agencies i s developing its plans rapidly. The American Medical As soc in tion is University of C & di for nia, Los Ar.geles, has been carefully
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and tothe Kanager of Snnta Fe Directed Operations. t o the Division of Bio1,ogy and Medicine cara ful study it was felt that the budget proposed by Dr. T.%.rren o f $1,250,000 w2.s not realistic in light of the limited physical facilities c vail able. The opa rating budget was therefore reduced t o $700,000 with the expcctation th z t the range of expenditure would probably increase during the year reaching a permanent levo1 of expenditure visualized at about on3 2nd one quarter million dollars per year. It is believed tht this reduction will make no impairment inthc program. In addition, approximc.tcly $200,000 i n government supplies will be z vail able, The dnngcrous laos l of radiation no longer exists at the Trinity Site. wire fence placed around the site. the entire arm for a bombing range s o no special security The guards h=va bcen ramoved and ahigh The Army is taking over will bc indicated.Dr.Stafford Warren proposos a resurvcy of th csi to this summer and c.n allotment of $71,000 for the. - co stent nile d has becn recommcnded, It i s recommcndud that one of tho smallcr sized betatrons,fac il it ios ,for its housing and mind quart crs be mcde available to Dr. Stone n t th2 Uni vcrs it y of Cnliforni?. Ho spit cl,the radiation f z c ili tics to bo n vail nbl c to
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approved invest ign tors of St zn ford Medical School of Medicine and University of Cz li for nia) This isto bo set up IS follows: Fiscal Yecr 1948 - depend upon the rscommcndction of the Bikini Re survey on of funds of the Eniwstok area i s of great biological importancs. Dr. Donaldson of the University of ' h shing ton hc.s gotten a, 2 group together for this. Arrangements are being made It is estimated that the cost involvsd will bc approxi- , 7. Iieport on Isotope Distribution Thus far Dr.keb z r sold has encountered no difficulty with the- free isotope distribution and believes that .A.Scion ti fic Exhibit for A scientific exhibit for the Amsricm Medical Association mccting and for the Ccntenary macting of the American Xs soci2tion for the Advanccrnent of Scionco i s believed an excellent education2.l opportunity for the Atomic Enere Commission to call to the at to nti on of the
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medical profession and other teachers of sci ance its interests and res pons ' ibi li ties .The Public Informntion Section of the Atomic Energy Commission,The Argonne National Laboratory, The Oak Ridge National Laboratory, the Resenrch Division and this Division are cooperating inthe development of such an exhibit. Suggestions as t o content are requested. Tha program i n Japan i s developing i n good shape. a f a i r number of competent Nisei available who are much into rested in obtaining positions.In addition, competent investigators are being obtnlned both on n short ,and a longer bxis. Construction of units to facilitate th g study Jis being begun ct Hiroshima and a t Kure. h budget of $1,850,000 sat up for Fiscal Year 1948, 1949, and $1,800,000 for 1950. It is planed that this progrzm can level nt $1,000,000 when the construction phases are completed. Good coopcr:Ltion is still being obtained from the Japanese. 10. Report tothe Chairmnn,Division of Medical Sciences, Mntional Research Council, on "Psychologic>l Aspects of R ndia tion Hazards .I1 11. Mouse Genetics Progrnm Location of Mousc Gonetics Colony a t Ozk Ridgo - The comnents of the Connittee on the accompnnying roport md my memorandum dz ted April 8, 1948 toDr. Holland vi11 be apprecizted.
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tothe staff a t Brookhaven and to thc Office of mew York inthe Brookhcven program and this will make for2 material strengthening of it. Dr. Van Slyke is taking cn nc ti ve interest The funds for construction have not been reduced as WE wish t o develop onple facilities both for the y;. brookhcven group and for gua st investigators. Tho psrsonne3 .. i n bioloRy has been Erozen at a level of 24 in the scientific group. This assumes that 20 o r more visiting investigators can be accommodated as soon as f - c ili ties are available.A totcl personnel in bio lom of nbout 48 i s envisaged.. Dr.Nims accepts this program. His oper f ting budget has been setat $438,000 with emphasis placed on the fact that a considorable share of this is to be used for guest investigators, hoped too btc in a competent mcdicnl director shortly and a total medical group of 10 i s planned. At present 15 bed are avGilrtblo in the hospital, It i s planned t o expand this t o /b ring the number of beds up t o 42 in the next few months. Ultramicrotome for the S action ing of Bone13. $$+' The Custom Scientific Instruments, Inc., o f Arlington,New Jersey, is interested in developing a microtome that can cut sections of und c calcified bone one quarter inch in diameter and 5 microns o r less thick. They nould nced five toten
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thousand dollars for preliminary exploration and fifteen t o twenty thousand dollars to produce the first model of such an apparatus. Does the Committee feel this rou ld be useful and worth the expense? 15. Place and time of May Meeting ofthe Advisory Committee for Biology and Medicine: