Minutes Advisory Committee for Biology and Medicine Eighth Meeting Held at Univeristy of California, Berkely, Ca., April 23-24, 1948(AEC-Acbm 8)

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ADVISGRY C/)hIMITTEE FOR BIOLOGY AND MEDICINE EIGHTH I EE TING University of California

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Advisory Cornnittee f o r Biology and Zledicine The eighth meeting of the Advisory Committee for Biology and Medicine of t h e Atomic Energy Comnission was convened by the Chairman, Dr. Alan Gregg a t 9:30 a.m. at the University of California, Berkeley, California. Present at the meeting were the following members: Det lev PI. Bronk being absent ; also attending were Dr. Shields Tfarren, Director of the Division of Biology Representatives of the University of California Minutes of The first order of business presented to the March 13, Committee by the Chairman was a discussion of the minutes of the meeting of March 13, 1948. Dr. Hastings made a motion t o adopt the minutes, motion was seoonded by D r . Wearn and unanimously approved, Fellowship Report on Progress of t h e Fellowship Program: Dr. Prarren outlined the membership of the various National Research Council Committeeswho are to select

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the fellows for the trair _ ing program and they are as Homer 1.”:‘. Smith, Chairman, Professor of Ph y sio lom Director of Physiological Laboratories, I\Jetv York University College of Medicine, New York, F. Y. Austin 3. Brues, Associate Professor o f Medicine, University of Chicago, Chicago, Illinois. Sam L. Clark, Professor of Anatomy, Van dc rbi lt University, Nashville, Tennessee. Hymer Louis Friedel l,Professor of Radiology, Ke stern Re serve Univer s ity, C leve 1and, Ohi 0. Joseph G. Hamilton, Assistant Professor of led i cine and Radiology, University of California, Berkeley, Roy R. Kracke, Dean, School of Xedicine, University of Alabama, Birmingham, Alabama. Douglas ‘%hitaker, Chairman; Professor of Biology, Stanford University, and Dean o f School o f Biological Sciences, Stanford University, Cn li for nia. Eric G. Ball, Professor o f Biochemistry, Harvard Xedical School, Boston, Massachusetts. J. 9. Bodine, Professor of Zoology, University o f Iowa, Iowa City, Iowa. Howard B, Lewis, Professor of Biological Chemistry, and Director of School of Pharmacy, University of. Michigan, Ann Arbor, Michigan. biology and Biophysics, University of Chicago,

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Post doctor zl Fellowships i n Biologiczl and Agricultural Sc isn ces University of Nebraska, Lincoln, Uebraska. Research Foundation, Universitjr o f Pennsylvania, Phil s delphi a, Pennsylvaniz. G. Zvelyn Hutchinson, Professor of Zoology, Ynle Uni ver sity, >JJZIV Haven, Connecticut . Ym. J. Robbins, Professor of Botany, Columbia University, and Director of New Ymk Botanical of Mis sour i, Columbia, Xis sour i . A general discussion followed on the program as t o tha number of men available at the various levels, and the urgency of getting the namos of the fellows before the committees for selection in time t o mset the entrance dates into the colleges md institutions. Grants ?.?ads to Train in a Ccnters The Committee endorsod the action of the Division of Eiology and Ilcdicine providing support to the follo ring training cent z rs : Bowman Gray School of Rkdicine, Wake Forest Pharmacological Actions on t h e Formation of Tissue Phospholipidcs ' Ifor one year beginning

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Bovmzn Grny School of ldcdicinz, %ke Forest and Turnover of Sodium and Potassium i n Acute Infections " for one year beginning July 1, "ldeasurcmmt of Volume o f Flov: of Elo odin the Kidney and Level of an Unanesthetized ?Jan by mcans of Radioisotopic Procedure - $5,000. of Tapeworms" and "The Effect of Relax in Extract of Corpora Lutea on Blood and Yxtra-Cellular Summer Coursas for Instructors A summer course has been arr m ged in two schedulcs, one a t Brookhaven i n July, and one a t Oak Ridge i n August. Thc course a t Oak Ridge will be an intensive laboratory for nia is now working with Dr. Joseph Hamilton i n charge of instrumentation at Oak Ridge. The Brookhaven course will be largo ly didactic and theoretical, Two men from each of the participating universities or schools have been assigned from the fn cult y momber group to attend m king a total of 28 men lincd up for the courses. The schools participating are the University of Oregon, Oregon State College, University of Oregon Medical School, Reed College, Duke University, University of North Carolina, North Carolina State College of

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Carolina, '?zke For cst College, Eaylor University, Colorcdo a t Dsnver,and University of Colorado c t Training at Columbin V n ivers it yin Biophysics--- arrangements a t Woods Hole for the summer fallowships. The problem of obtaining space for the training of health physicists at Columbia was discussed. Dr. Hastings suggested thzt it might be feasible to develop sprcce facilities at Brookhaven for such training rather than increasing buildings at Columbia University, It was recommended by the Committee that Dr.Fail la mzke a study o f tho problem including the availability of space a t Columbia, and report his findings to the Committee. Dr.Fail la revert ad to the courscs that arc schedu led to be given at iioods Hole r.nd explained th nt the studies vrould be for young psopl;. thnt have worked previously with rr dio act iv cm nter i zl s and who choose t o study problems in rz dio biology cnd bio lou with the use of radio iso to pcs. This study should enable the students to establish a nuclous of interest in other places. In further connection with the training progrcm Dr. Warren reported that it hcid been necessary to

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incrz - s e thi. 2ll occ tion of funds to the University of RochGstcr from $;G15,000 t o $1,091,000 to build the building th z tis to be used for the tr rini pg program. Such increase of cost TGS caused by the previous csti - mate being two years old, in crea so in the size of the building and general inc rez se of cost of labor cnd MI-. John Derry explained tothe Committee about his recent western trip. At cl even a.m. the Committeo edjourned foran in sp z c tion of the 154'' Cyclotron. Dr.Ernest Lawrence conducted the tour forth a Committee, Presentation of Prog rm Outlines by Dr, John Dr. Lawrence outlined briefly the work now being carried on inthe Donner and Crocker Laboratories. The program ofthe Donner Laboratory consists of eight items: 1. Biological Effects of Nuclear Fission in Vivo. 2. i3iological Effects of High Energy Particles from 3. Studies on the F2echanism of Radiation. Damage t o Tissue and Possible Prophylactic or Therapeutic klanagement of Radiation I n jury. 4, General Studies of the Biological Effects of

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Standardization of Calibration of Radiotictive Trace Element Analysis in Biological Tissues by Induced Fadioactiatity. Training of Personnel in the Biological and Medical Applications of Ruclear Physics and Chemistry and in the Field of the Biological Effects of Irradiation. Study of t h e Biology of Carcinogens. Dr. Hamilton outlined very briefly the work he i s now undertaking and brought to the attention of the Committee the following statement which was included in the report of his activities : "The major portion of the program, which has averaged about 70% of the to t nl effort, has b sen directed to the metabolic studies. to exploring inconsiderable detail the possible mechanisms rz s pons i ble for the rather unique and dangerous predilection of plutonium and a number of the fission products for deposition and prolonged ment of possible methods for the detection and treat - ment of radioactive poisoning by the so agents. remaining $2 of the total endeavor was devoted tothe plant and soil studies." Roughly 25% has been allocated Dr. Stone presented the need for radiation facilities and animal quarters. After discussion, it was felt th::t the work a t San Francisco wns a useful zd jun ct to th z tat Berkeley, and that as far as possible the San Francisco facilities be made available to the Stanford Medical Faculty. After furt hsr discussion, it seemed th?.t a small botntron would probably be the most serviceable radiation source

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t o be sst zb li shed. The question of 7. I.ledicn1 Bcerd o f $150,000 for F.Y. 1950 rnd with further all om tion of funds t o be m6ae upoli recommendztion of the Committee. Moved by Dr. Besdle, seconded by Dr. Goodpcsture and Re search The Committee endorsed the action of the Division Report on Support of Research Projects of Biology and lk di cine in approving the following projects : the Individual Cells in Available Body Secretions, i.c. Or21 and Vrginal, of Animzls Subjected to Deep i calE ffcc ts of Rc diz tion from bce s sive Amount of 1-131 inthe Organism, and Various Physiological Phcnomena and Z-vents Studied w i t h 1-131 as a Tracer" - The Committee endorsed the action of the Division of Eiology and llcdicine in declining th2 following pro j z ct : of Dyspnec. 2nd Disc bil it yin l'sticnts vith Chronic Research Research Projects for Conunittee Considerction Committee Yassachusctts Institut d of Tcchnology - Dr. Robley Consideration Exns - Radiomcdicino Research The Office of Nzval Research presented to tho

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Division o f BioloE,y ar,d Tledicine a second proposal incsmuch as the Committee w2.s of the visw that this part of the prcposcl night over l rp with the previous proposal approvod by the Committee ctits mezting held 'on Febru?.ry treatment by mezns of super voltage rcd in tion. After very to trez t patients vith high voltage rad in tion in an insti - tut ion not zquippod with hospital facilities.In light of this Dr. TrLTp's request for support of a contract was $15,000 be allocated to Dr. Evans for Part I11 of the and vi ric i dal zgent proposal, namely: the b act - ric i dal effoct/of cathode ray. Dr. Ilcstings moved that the recommendntion be app ove d.Dr. Stnkmm seconded the motion and it w':s Part IV of the prop os4 WAS concerned with ccthodcthat this rr x not within the province

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mental and Clinic rl Invest ig - tion upon Various Aspects of Chronic Pulmonary Disease ;:raifested by Persons Associ2ted with the Industrial Production and Use of Dr. Yarren discussed in dc tail the beryl los is problem i n connzcticn with the props al submitted by Dr. iforwald for the Trudeau Found.:.tion a t Sarsnnc Lake, Foundotion wqs a good place for experimental work. Dr. Warren stated that tho State Health Commissioner of Pennsylvania had stated in writing th ct there were no hazards involved i n beryllium. Thc Beryllium Corporation of Americn has widely exploited this statement. After discussion of various nspects of the problem, it was thc opinion of the Committee that beryl los is is a very real hazard and one which tha Commission should make every effort to control. Further, thzt it was a proper responsibility of the Com&ssion to publicize the danger of beryl los is,both acute and chronic, including the fact that hazards exist even t o persons not employed in the plants utilizing beryllium but adj xen t to them. Dr. Warren recommended thct the Trudeau research project be approved in principle subject to final c lak if i cation by the Division cf Biology and Medicine

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motion t o approve the recommendatisn, and motion W ~ S seccndcd by D r . Goodpzsture and rpproved unanimously Dr. Xarren reported on the free distribution of isotopes as being carried on by Dr. Paul C. Aebersold atthe Oak Ridge Laboratory successfully.Afull discussion wzs made on the use of radioactive cobalt as a replacement for radium o r radon in the t rect ment of cancer. Dr.Far rens tnt ud that good headway vas being mcde in the possibility of isotope farming. Scientific Scientific Zx hi bits nt &&A for il AS tion meeting and for the Ccntenzry meeting of the iim2rican As s cci ation for tho Advancement o f Science i s bolievad an excellent educational opportunity fc r the Atomic Energy Co mission to call attention of the medical profession 2nd other teachers of science tc its interests and responsibilities. The Public In f ormntion Section of the Atomic Energy Commission, The lirgonne Na tic nal Laboratory, The Oak Ridge Nz t ional Laboratory, the Research Division qnd the Division of Bic,logy a d Medicine are cooperating inthe development of such an exhibit.Dr, Hastings suggested that the University of California be invited to

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made on tho progrnm ir. Japcm. ia full discuss i cn follo1rli.d. 6 budget of $1,850,000 has beeq apprpvsd by t h e Atonic Energy Commission for the fiscal yew 1948, 1949, and $1,800,000 fc r the fiscal year 1950 for the cnr ry in gout of the work as outlined by the6tc nic Casualty CmmAssic?n. Criticism was mcde on the lnck of co operatic n by the Army especially in the exchange of dollars for yen. discuss the exchange Tf funds and report their findings tothe Committee. It was further reconmendi.d that Dr. Philip Owen be asked t o present afull budget Just if ' ic2tion at the next meeting. Rad iati on Report tothe Chairman, I.ledica1 Sciences,Nn tic nal Research Council. Dr. Vhrren s mmr iz cd the final report of the mzeting held January 22, 1948 and analyzed each item. This rcp crt was presented primarily for information. In a discussion sf the recon2sndrtians, the following comments wsre made: First,that the report was not prim n ril y de ding with psychological a sped ts cf ra diz tion but rather with the psychological aspects of any major 1. Pre px z tid n cfa list of places and in diy i duds throughout the coufitry whence in form rti on may be may be evalucted,

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2,nd incliit duals be prdparcd through3ut the cow try SO th z t re ccm a end c tiw cnd the rez c tion of the Com;nittec was thzt no cc tic n shculd bc taken locking t3tho implementztion I t i'ic.s felt that this night be avery (!ang:rcus of such a recommendation. 2. Preps rat i cnn fa series of booklets or ct her suitable materizls containing fr n nk,factual in format i cn on thecb3actives and activities of the Atomic Energy Commission. This series sh w ld include a descriptive list cf ,!+tonic Energy Conmission can tractors and their There was gen2ral approval of +his recommendstion providcd due care ms taken in the prep nr sti on of the booklcts t o ?-void my aspects suggesting propaganda. 3. Prepar?.tion sf one c r more bzsic primers on atcmic That was unznimiusr rpproval of this recommendatlon. 4. Convening of cc n ferm ces similar to tho present I t wcs felt th2.t recommend:.tion 4 was cut of the pravince of this Cormittee. 5, Provision of a de qu st ely infsrmed spezkers f2rall conferences G r conventions involving edu cc tors,jour x lists, broadcasters,etc. This Gbvicusly would invnlve the active ccoperr.tion of state and priv zte universities and the varicjus I t vas felt that recomnendntion 5in s cut …