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Michigan , Ann Arbor, Michigan Conference Room - Cooley Memorial Laboratory, North Campus Welcome t o The University of Michigan Dean of the Medical School Welcome tothe Michigan Memorial-Phoenix Project Professor Wm. Kerr, Acting Director Tour of Phoen'x Me ori al Laboratory and Ford Reactor Phoenix Supported Activities i n Chemistry Phoenix Supported Activities i n Physics Samuel Krimm, Ph.D., Assoc, Professor, Physics Phoenix Supported Activities i n Nuclear Engineering Chichiro Kikuchi, Ph.D., Professor, Nuclear Engineering Luncheon - Michigan Union - Founders Room 1 ~ 3 0P.M. - Some Legal Aspects of Radiation Biology Research The latent and non-specific characteristics o,f some radiation injuries create extremely difficult problems for the law. One possible solution for injuries such as leukemia and genetic damage may be creation of a contingent injury fund based on statistics developed from radiation biology research. Conference Room, Cooley Memozial Laboratory, North Campus
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The absorption and fate of C14-Thio-TEPA w a s investigatedI t in' human cancer patients $and i n normal dogs. indicate that the drug ' i s poorly absorbed after oral administration inpatients with noma1 gastrointestinal medt of absorption of the drug a f t e r oral adminiStration. A portion of the drug i s metabolized t o TEPA Suggestions are presented for the enhance- 11 A large number of organic bases are - actively ' secrete dI 1 taneously occurring active reabsorpticn inthe same portion of t h e nephron; be impermeable to choline, The distal. tubule was found t o 2:30 P.M. - Isotope Rate Effects in the Condensing Enzyme Readtion Paul A. Srere, Ph.D., Assoc. Prof,, Biological Chem. The reaction catafized by citrate condensing enzyme was studied using deutekated substrates, Isotope rate effects were observed and poasib1.e inter greta - tions were made for these observations. 2 ~ 4 5P.M. - Use of Isotopes f o r Studying Amino Acid Transport "Amino acids labeled with GI4 have been used for studying the kinetics sf amiko acid entry and exit with Ehrlich Ascites cells, Most of the neutral. amino acids are accumulated t d high levels inside the ee'lks, ratio of a given amino acid is a consequence of the rate of esoape of the amino acid relative to rate of entry. Amino acids with large hydrocarbon side chains have high initial entry but because of correspondingly high ef fluxes ' are not strongly concentrated. a-aminoisobutyric in contrast show slow initial entry but reach very high cellular levels because they escape, By measuring the competitive relationships among the neutral amino acids we have been able to ascertain that the exic process i s one of two distinct entry processes. The final distribution
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30.00PoMo - In activation of Antibody by Gaplma Radiation In activation occurs by a combination of two mechanisms: Reaction of rad to lysis products of water with critical groups i n11 the combining sites, and by overall molecular Visit to Botanical Gardens Peter B. Kaufman, Ph.D., Asst. Prof. Botany, Curator, Ann Arbor Town Club