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I 15, 1963 BIOLOGY AND MEDICINE A list I S presented of papers published from Sov. 1960 to April 1961 by Unitcd Kingdom sources covering various phases of radiobiology and allied subjects. (C.H.) 2823 (RADC-TDR-62-102) THE EFFECT OF hllCROWAVES ON THE RESPONSE TO IONIZING RADIAAtomic Energy Project The interaction of different f o r m s of energy that result in antagonism o r modification of response in the organism is a recognized biological phenomenon. Evidence was obtained that dogs exposed to a physiologically tolerated level (100 mw/square cm) of pulsed microwaves (2600 rnc) a r e less sensitive to ionizing radialion than animals not previously pretreated with microwaves. Simultaneous exposure to ionizing and microwave irradiation results in earlier granulocytic recovery than is seen after ionizing radiation alone. Protection by enhancement of recovery processes i s considered. Lethality from whole and partial body ionizing radiation dter exposure to microwaves i s reduced depending on duration of previous microwave exposure. The results indicate the need for additional work with consideration of time-intensity factors of both f o r m s of energy to permit the evaluation of these procedures in modification of injury o r enhancement of recovery after ionizing radiaRome Air Development Center, ING LETHAL Co" IRRADIATION. Anna C. Garner, E. Statea Wynne, Walter M. Sellers, and James E. Xloyer (School of Aerospace Medicine, Brooks AFB. Tex.). 2 , 5. 8, 11. and 14 days after exposure to Codagamma raditlon approximating the LD,*. Bacteriologic cultures showed only one positive blood. B acte rid invasion of the submandibular node after 14 days and of the stomach wall at all postirradiation intervals of 5 days o r more was statistically significant. Of the 15 Salmonella and Shigella organisms detected in animals succumbing or sacrificed, 5 or more days postirradiation, 1 0 w e r e present in the BIBLIOCRAPHY. A List of Reports Submitted to the United Nations Scientific Committee on the Effects of Forty-nine Macaca mulatta monkeys were sacrificed A list is presented of reports submitted between hlafch 1. 1961 and April 2, 1962 to the United Nations Scientific Committee on the Effects of Atomic Radiatibn. don tri but or s included member nations and certain interet ional agencies and organizations. fC.H.1 0 Es. PART I. EFFECT OX ATP: CREATISE PHOSsults for Period March 1, 1962 through February 'S, 1963. The adenosine triphosphate-creatine phosphotransferasc w'as assayed in samples of protein and enzyme previo usb irradiated. Whereas in the intact protein solution histidine i s most radiosensitive, methionine was found to be most labile in the corresponding amino acid hydrolysate in solution. Phenylalanine and arginine were also destroyed faster in protein hydrolyzed before radiation exposure. Incorporation into a polypeptide chain altered the radioinduced chemical changes. The decline in enzymatic activity was m o r e rapid than the disappearance of -SH groups. The relation of -SH groups to enzyme activity and radiosensitivity of protein compounds i s discussed. Amino acids formed by interconversion as a result of the y irradiation of peptide were identified. Data are tabulated. The mechi anism involved in the formation of as part ic acid from glutamic acid and concomitant CO, fixation was investigated in poly-L-glutamic acid irradiated in the presence of NaHC"0,. Radioautogroms indicated activity in the position for aspartic acid. Possible reaction mechanisms inAND EVALUATE RADIOISOTOPES FOR TELETHERAPY; Progress Report. (Arkansas. Univ., Little Rock. School of Medicine). July 23. 1956. Contract AT(40-1)-1771. 33p. The installation, calibration, and pr&&n survey are described for a Cow teletherapy unit. Data a r e summarized for 227 patients with various types of neoplasms treated with external y radiation from the Cow teletherapy unit. 2828 (TD-17170) TO INVESTIGATE, DEVELOP, AND EVALUATE RADIOISOTOPES FOR TELETHERAPY. Progress Report. (Arkansas, Univ., Little Rock. School of Medicine). July 1, 1958. Contract AT(40-11-1771. 24p. Results are summarized for the use of focused grid telecobalt therapy in the palliative treatment of 45 patients with advanced cancer. bl at iv ely large doses of radiation were delivered o v e r a period of 10 treatment days. Pain and hemorrhage stopped and there was marked regression in tumor size In 211 cases. Data are summarized on 670 patients with various types of neoplasms treated with exAND EVALUATE RADIOISOMPES FOR TELETHERAPY. Progress Report. (Arkansas. Univ., Little Rock. School of Medicine). July 1, 1957. Contract AT(40-1)-1771. 19p. Safety procedures and t h e calibration of a Co" teletherapy unit are described. Investigations were begun on the utilization of a grid with telecobalt. Data are summarized on 317 patients with various types of neoplasms who reLIFETIME SICKNESS AND MORTALITY AND PROGENY INC IRRADIATION. Summary of Progress, 1962. John W. Cowen and Janice Stadler (Iowa SLate Univ. of Science and time fertilitr and total life-time number of progeny in mice were studied. Pronounced s e x differences were noted in the response to radiation. Acute irradiation s of from 0 to 320 r scarcely affected male fertility or litter size, while in irradiated females the number of litters ad number of progenies decreased regularly beginning a t doses of 20 r. Irradiation to either parent had no influence on the sex ratios of progeny. Chronic effects of whole-body irradiation on progenies and sex ratios of first litters werc measured f o r each of 10 continutng generations folloa.lng exposure of lhe f i r s t generation and exposure of all generations to 22 hrs,day continuous 7 irradiation of from 1.3 to 2830 (TID-17189) A QUANTITATIVE STUDY OF