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Institution(s) : (1) University of California, San Francisco ( 6 ) Oak Ridge I n s t . of Nuclear Studies Short Description: (1) During the years 1956 t o 1958, 67 patients were irradiated with 70 MeV x-rays from t h e synchrotron. Doses were 5250 R in 5 weeks or 6000 R in 6 weeks. the oral cavity and carcinomas of the cervix were treated. Patients with bronchogenic carcinoma, tumors of Fol low-up Data: I n August 1958, o f the 67 patients treated, 25 had died within 2 years of starting treatment. as of June 1962, 310 patients had been treated but survial data is not A subsequent report indicates that (2) A cobal t-60 teletherapy unit was used to treat 227 patients with various (3) From 1972 t o 1979, Hodgkin's disease and other lymphomas were treated by a combination o f laparotomy t o improve staging and diagnosis, and carefully pl anned radiation to indicated organs o f invol vement. A number of mal ignan - cies were treated with ultra high dose rate electrons t o study the effects of t h i s radiation. Chromium-51 radioactive permanent imp1 ants were a1 so evaluated. Head a n d neck mal ignancies were subjected t o combined treatment schedules, including d r u g pre-treatment and spl it-course radiation. The sensi t i zi n g qual it i es of hydroxyurea and cytosine arabi nosi de were tested on .a hair follicle indicating system before'being tested on animal tumors and
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(4) From 1963 t o 1965 joint study was being carried out in conjunction with the Ear, Nose, and Throat Clinic in an attempt to evaluate the effects of preand post - operative radiation treatment of various malignancies using the Van accelerator electron beam. randoinized for treatment schedules. I t was believed that some lung mal ign an ies were made operable by irradiation. A11patients were seen i n the ENT C1inic and Fol1 ow-up Data: One patient having an inoperable gastric mal ignancy treated with a combination of colchicine and radiation was still alive and gave no evidence of the disease after2years. (5) During the period 1952-1966, cobal t-60 and cesium-137, tele therapy units were used ina comparative clinical evaluation in the radiation treatment of employment of a cesium-137 source was achieved and the radiation from this isotope was applied clinically to evaluate the potential role of this radiation in clinical radiotherapy i n comparison with cobal t-60 radiation and past and current experience with ortho voltage radiation. Modification ofa theratron-B t o permit clinical (6)In 1966, t o determine the effects of cobal t-60 tele therapy on certain kinds of cancer two patients were given 500 Rto spleen and liver. patient showed no hematologic changes when the liver was irradiated, but a profound fa1 1in circulating white blood cells occurred after irradiation of un distinguishable from the changes occurring after spleen irradiation ; i n both instances the peripheral white count went from about 100,000 t o 20,000 with a fast return to pretreatment levels. The other patient responded to1iver irradiation in a way (7)During the period 1964-1967 ina study of the optimal tumor dose i n radiation therapy of cancer of the esophagus, half of the cases treated received cobalt tele therapy doses of 5000 roentgens in four weeks and the other half received doses of 6000 roentgens i n six weeks. dysphagia and twelve months survival were compared i n each group.