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Project Catecjory: Tel etherirpy with Particle Eeams ( 3 ) Univ. o f California, San Francisco Objective(s) of Project : l o determine possible beneficial effects in various neopl a stic and metabol i c diseases Short Description : (1) I n the period 1953-1959 the pituitary glands of patients w i t h advanced metastatic mammary carcinoma or other endocrine related diseases were irradiated with beams from the 184 inch cyclotron a t first with the 340 meV proton beam, later with the 900 meV alpha particle beam. Doses o f ' 24,000 t o 30,000 rad t o the pituitary were given. (2) Heavy particle irradiation was used (1968) for the irradiation of the pituitary in acromegaly, Cushing's disease, and chromophobe adenomas of the pituitary and i n metabol i c disease such as diabetic Fetinopathy, metastatic breast and prostatic carcinoma where these are sensitive to hormonal control through the pituitary or the endocrine end organs of the pituitary. particle irradiation was used for direct tumor irradiation at other sites in the body where the tumor boundaries can be adequately delineated. (3) Since 1975, 94 patients with localized unresectable carcinoma o f the pancreas have been irradiated using helim and heavier particles. Fol low - up Data : (1) By April 1959, 103 patients had been treated. Clinical and laboratory studies were conducted every 4-8 weeks on survivors. nine of the 82 with metastatic carcinoma were living in 1959, the longest being 4 years post irradiation. (2) Four hundred and twenty six patients have had heavy particle therapy. In the series of 66 patients with acromegaly, 90% have hada complete amelioration of their disease process establishing heavy particle irradiation t o the pituitary as being the optimal form of treatment a t the present time. Highly successful resul ts have a1 so been achieved inpatients with Cushing ' s disease and i n 10 patients with chromophobe adenomas. diabetic retinopathy are promising, but require longer fol low-up for The results in
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.(3) Hany patients proved to have occult liver metastases manifested within9 months post treatment. primary neoplasm (approx. 20%) has been difficult to obtain even with doses surgical bypass procedures since irradiation has n o t been successful i n re1 ie ving obstructive sy : : 2toris. Evidence o f gastrointestinal injury has been present i n postradiation therapy in approximately 10% of patients. In, addi tion, local and regional control ofthe Ga:,tric and b ilia ry obstruction have required