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TITLE: t ff ect s Of Ionizing Ila di ation 00 tho LOCI TIO l : Sert t lo, VA ra stica lar ? unction of Ran dot ermine the effect of sing lo do sea of ionizing radiation on the to st as of normal the ob lec tires hare boon numor ~ ~ si n clu ding tho do to rmi nation of doso - ros pons a ro lat i oar hips.Parr mo term moasurod in clu do sperm count and morphology: oxamination of testicular bio psi os(Sertoli colls. Loydig JCSR, estrogen, to s to st crone,prog n and lol and prag na net riol : plasma ?Sn, ICSR, and to s to ster ono.net hod ology in clu dos tho uno ga ant it ation. cell mo amro mont, his to chemistry and a loc tro a micromcopy. Or j nary and plasma ?SR lor ol s in cro a seas the gera in slo pith alio a is do plato d. Plasma ICSR not. Eosms o f 1OOr and aboro causo temporary vis in ie by 16 minutes after X-ray. Ilo core ry i a ccea s a after600rand urinary tes to ster oae levels da cro as e slightly. A6STRllCT: Pasearch is being carried oat t o OPrRnrxows orrxct: Oak Ridge LOCATIOR: Lubbock, TI tast is : An t loc tron nic ros co pic Cyto chemical ASPLRAIA: SLI II IF Z ROUS TU60LtS: RURAI ABSTRLCT: lorma]. human tc s to s which bare ro col rod are sab j acted to an ol act ron microscopic c ~ to chr a ica la x ami atl on to determine tho off oct s of irradiation on thom b cellular at nic tara and function of the testis. Tho testis is JU or tre aol y radio sens lt irt timsoe. l no a rly irradiation a ff oct is the broakdown of sperm a to gon i al calls which leads to a roo a per a i a. Tho reappear an co of the of tha ruovory procasm. Lowirer, the tiling of ca plato rep opal ation of tho mom in if ero u8 tuba las is doso d open bon tra dray roquito wovarrl yoars for high doaos. In addition to thoso 8orph o logic a1oront8. it bas boon mg gor ted that irradiation mar rltor tbo loa lita tio a of rarioas oazymas. @a oxamino bio p do sob tai a od from a fw minutes to wv oral months after irradiation tod of in o chaag.6 that occur intho mbcollalar st net n ro and in on zy a ic local it at ions during mp or mato gon i aldo goner rti on and th oro co rory procus. Our rosalts with tho irradiated material aro cap a rod mi th that ro have found to occur i n normal, non - ir radi a tod haman ph os phat as a,thiamine pyro phosphatase, and various o thor naclo osi do 11- and trip hos pha tuo s. tpxs 006086: EX otoioi: ALTBX 07 : .crl Effects of Ionizing Radiation .are Coll u lar, mad inman Larol :tUTIOl: Onirorsity of Boc bo star, ABSTrACT: L call cy clo analysis of the in cid on a and npair of radiation - indo cod sing10and dou blast rand DNA breaks rill ba don. with L5170T and 11.1. cells. Tho ro pair of single and particularly of doable strand breaks rill tango has already 8hown that in s ~ chrono u8 -La cells,ro pair of sub lot hal damago accars toa much groat or ox tant, if not axclusirolr, daring C(1) and lateSt hand n ria goth or st agos of thor op lica tio a cycle. sinco tha Dol acul arr o pair ros poa sib la for the r Op & i r of sab lot hal damage should a lao occur to a each groat era x tont at t horst ago a. Tbm plan arian will bo used as a mSda1 system for t host a dy of stom coll population kinetics, part ical a rly vi thro gard to tho loss o f d lf for oat i at ivo into grit ? and tho animal * . mochWai8*(S) for the control of diff or anti ation. Lang has al road y shown tho ol le fulness of the plan arian for sach studio8 .ad rork rill continuo along tho marno lines. L study of for nr plato nia m workors with plato niu a body bar dons will ba conti a a od and t boron gh mod italo x ami nation,in clad in guri no an alp is and lung counts. of IS many of tbro man as p ossi blow ill bo por foca ed.A ETStOm for automated gradient an a lys l8 has boon dr ral a pad and constructed,such that r x pr ria on tal point8 may be tak an over7 two boon outfitted and arol at i roly local mOurCa of Duqosfa lug u bris has boon found.