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Ofice Memordndam UNITED STATES GOVERNMENT FROM : Paul C. Aebersold, Chief, Iso tops Ijirisian Reference is made t o communication of August 1/'-1949, sent t o you by Dr. Shields Warren, Director, Division of Biology and NedicirLe, regarding allocation of radioisotopes tobe used i n human subjects. noted that Dr. Warren instructed that such allocations would be made by the Isotopes Division only after review and approval by the Subcommittee on Euman Applications of t h e Comittee on Isotope Distribution. It should be emphasized that the instruction applies even though the radiomaterial i s produced in the laboratory where it isto be usedr Since t h i s procedure has not been uniformly followed in the past, we are viriting t o acquaint you with the appropriate de teil s. of our latest catalog. governing the distribution of radioisotopes when these substances areto be used in humans. Circular D-4, which contains the same statement, and which may prove convenient t o you in t h e process of acquainting members of your staff with Cbviously applicants for radioisotopes t o be used in human subjects will need t o submit more information than has been offered on previous applications submitted on Form AEC-558, For the convenience of this office end of t h e Subconnittee on Humen Applications, epplications should be submitted on Form AX-313. information asked for on pages 30 and 31 of the Catelog and Price List No 3, July 1949. W e shall assume, as .in the past, that instrumentatian, both for measurement end for health physics purposes, is adequate at Ccanmission laboratories. It will not be necessary t o use Part 2 of Form with all projects in which human subjects are used, so as t o insure that the clinical care of the patients will be provided foro It should be emphasized t h a t each application should be accompanied by a formal, written endorsement, signed by the Chairman of the local "Isotopes CommitteeJn the recornended membership of which i s outlined on pages 30 and 31 of t h e catalog. Your special attention is called to the Subcommittee's insistence thata complete dosage schedule be submitted with the application. On pages 30 and 31 are presented the criteria Enclosed a l s o ere six copies of Isotopes Divisids Special attention should be given tothe The Subcommittee has jn s is ted that a physician be conneoted Repository: NARA Atlanta Archives OR Division of Research