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’ PROGRESS AND RESULTS: IC June 1962, seven additional patients have been studied. Five patients received 200 rad mdme dose; one, 150 rad; and one patient received 0.4 mg/kg of intravenous nitrogen mustard. The patients who received 200 rad were calculated to have received from 290 to 25 r in air at the midplane. The clinical syndrome conformed to that which has been reprted except in one aspect. Tubiana et al (Diagnosis and Treatment of Acute Radiation Ln~ury), World Health Organization, 1961, p 241 reported, “During the actual exposure, shen the dose reaches 150 to 200 rad, the patient expertences a sensation of asthenia, with I tendency to nausea, and exhibits tachycardia, pallor, and anxiety.” In only one patient, s%o had obstructive nephropathy due to carcinoma of the cervlx, did we see a similar syndrome with nausea and vomiting. Hematologic data w a s similar to that reported previously. kreased excretion of xanthurenic acid was found in two of five patients treated with 200 rad. These same patients excreted increased amounts of parahydmxy phenylacetic acid, a tyrosine From the period of the last report, 1 November 1961 through rpd: No. 03.009 wlbtal n i l e : Metabolic Changes in Humans Caractor: Univ of Cincinnati College of :-ut the metabolic effects of total-body and partial-body irradiation so as to have a **r understanding of the acute and subacute effects of irradiation in the human. n e initial studies pointed toward the elucidation of biological indicators of radiation &cis in humans. The major parameters being investigated at present are urinary aminorlduna and alterations in immunological patterns. Certain other parameters such &9 :Facine and creatinine excretions and hematological effects are also being followed. I %fiingAgeocy: DMA Telephone: Oxford 7-7615 CLASSIFICATIONof the information on this page is: UNCLASSIFIED These studies a r e designed to obtain new informaInterim Reports: 91 October 1962 Estimated Date of Final Repork 1969 Plans for Next Period: During the next year, studies will continue as were outlined pre- ‘iiously. These involve clinical, hematological, and biochemical evaluation. Iuvestig~dions of breakdown products of DNA and vitamin B, metabolism will be extended, Chromosome counting of leukocytes to determine possible changes following irradiation is underway. hstitution of autologous marrow transfusion techniques is proposed since the present dose levels cannot he exceeded without possible hazards to patients unless 6uch support is available for doses of 250 to 350 rad. Perfection of phage testing of antlbody response 1s being continued. T h i s approach may offer a better method of esdmating the immunologic damage PJ a result of radiation.